• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. KPNB1

KPNB1 (Karyopherin subunit beta 1)

Loading...

The Function of KPNB1

Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Importin subunit beta-1

Short name:

PTAC97

Alternative name(s):

Importin-90
Karyopherin subunit beta-1
Nuclear factor p97
Pore targeting complex 97 kDa subunit

KPNB1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11870935 (KPNB1) ??
  2. RS8070463 (KPNB1) ??

Top Gene-Substance Interactions

KPNB1 Interacts with These Diseases

Disease Score

Substances That Increase KPNB1

Substances Interaction Organism Category

Substances That Decrease KPNB1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT1
  • STAT1beta
  • STAT1alpha

Gene Pathways:

  • Metabolism
  • Disease
  • Immune System
  • Apoptosis
  • RNA transport

Molecular Function:

  • Enzyme Binding
  • Nuclear Localization Sequence Binding
  • Poly(A) Rna Binding
  • Protein Domain Specific Binding
  • Protein Transporter Activity
  • Zinc Ion Binding

Biological Processes:

  • Apoptotic Dna Fragmentation
  • Astral Microtubule Organization
  • Establishment Of Mitotic Spindle Localization
  • Establishment Of Protein Localization
  • Intracellular Transport Of Virus
  • Mitotic Chromosome Movement Towards Spindle Pole
  • Mitotic Metaphase Plate Congression
  • Mitotic Spindle Assembly
  • Modulation By Virus Of Host Process
  • Nls-Bearing Protein Import Into Nucleus
  • Protein Import Into Nucleus
  • Protein Import Into Nucleus, Docking
  • Protein Import Into Nucleus, Translocation
  • Ran Protein Signal Transduction
  • Ribosomal Protein Import Into Nucleus
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Importin subunit beta-1| A306_06266| Anapl_14902| AS27_13256| AS28_14427| imb1| Impnb| importin 1| importin 90| importin beta| importin beta-1 subunit| importin subunit beta-1-like protein| IPO1| ipob| karyopherin beta 1| karyopherin,beta 1| karyopherin (importin) beta 1| karyopherin subunit beta-1| M91_05245| M959_07503| N300_06089| N301_16687| N302_11349| N303_13343| N306_02908| N308_16167| N309_09750| N310_12844| N311_04414| N312_04054| N321_12831| N322_03251| N324_08248| N325_12089| N326_04402| N327_07818| N328_06546| N329_13135| N330_07395| N331_12399| N332_04097| N334_07368| N335_09445| N336_08485| N339_08568| N340_01004| N341_01275| NTF97| nuclear factor p97| PAL_GLEAN10019656| PANDA_004988| pore targeting complex 97 kDa subunit| PTAC97| SCG| UY3_09091| Y956_11189| Z169_16365| kpnb1

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved