The Function of KPNB1
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus.
Protein names
Recommended name:
Importin subunit beta-1Short name:
PTAC97Alternative name(s):
Importin-90Karyopherin subunit beta-1
Nuclear factor p97
Pore targeting complex 97 kDa subunit
- RS11870935 (KPNB1) ??
- RS8070463 (KPNB1) ??
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Top Gene-Substance Interactions
KPNB1 Interacts with These Diseases
Disease | Score |
Substances That Increase KPNB1
Substances | Interaction | Organism | Category |
Substances That Decrease KPNB1
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Enzyme Binding
- Nuclear Localization Sequence Binding
- Poly(A) Rna Binding
- Protein Domain Specific Binding
- Protein Transporter Activity
- Zinc Ion Binding
Biological Processes:
- Apoptotic Dna Fragmentation
- Astral Microtubule Organization
- Establishment Of Mitotic Spindle Localization
- Establishment Of Protein Localization
- Intracellular Transport Of Virus
- Mitotic Chromosome Movement Towards Spindle Pole
- Mitotic Metaphase Plate Congression
- Mitotic Spindle Assembly
- Modulation By Virus Of Host Process
- Nls-Bearing Protein Import Into Nucleus
- Protein Import Into Nucleus
- Protein Import Into Nucleus, Docking
- Protein Import Into Nucleus, Translocation
- Ran Protein Signal Transduction
- Ribosomal Protein Import Into Nucleus