From NCBI Gene: High molecular weight kininogen deficiencyFrom UniProt: High molecular weight kininogen deficiency (HMWK deficiency): Autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. [MIM:228960]

     From NCBI Gene: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014] From UniProt: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

The following transcription factors affect gene expression:

• AhR
• PPAR-alpha
• C/EBPbeta
• FOXO1
• FOXO1a

Tissue specificity:

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

Molecular Function:

• Cysteine-Type Endopeptidase Inhibitor Activity
• Receptor Binding
• Heparin Binding
• Zinc Ion Binding

Biological Processes:

• Platelet Degranulation
• Inflammatory Response
• Negative Regulation Of Cell Adhesion
• Positive Regulation Of Cytosolic Calcium Ion Concentration
• Blood Coagulation, Intrinsic Pathway
• Negative Regulation Of Blood Coagulation
• Vasodilation
• Positive Regulation Of Apoptotic Process
• Negative Regulation Of Proteolysis