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  3. KNG1

KNG1 (Kininogen 1)

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Summary of KNG1

The gene codes for a protein, kininogen 1. It generates HMWK and LMWK. HMWK is used for blood coagulation, but LMWK is not [R].

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The Function of KNG1

(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Protein names

Recommended name:

Kininogen-1

Short name:

HMWK

Alternative name(s):

Alpha-2-thiol proteinase inhibitor
Fitzgerald factor
High molecular weight kininogen
Williams-Fitzgerald-Flaujeac factor
Ile-Ser-Bradykinin
Kallidin I
Kallidin II

KNG1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11924390 (KNG1) ??
  2. RS1656966 (KNG1) ??
  3. RS4686799 (KNG1) ??
  4. RS5030062 (KNG1) ??
  5. RS698078 (KNG1) ??
  6. RS710446 (KNG1) ??

Top Gene-Substance Interactions

KNG1 Interacts with These Diseases

Disease Score

Substances That Increase KNG1

Substances Interaction Organism Category

Substances That Decrease KNG1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: High molecular weight kininogen deficiencyFrom UniProt: High molecular weight kininogen deficiency (HMWK deficiency): Autosomal recessive coagulation defect. Patients with HWMK deficiency do not have a hemorrhagic tendency, but they exhibit abnormal surface-mediated activation of fibrinolysis. [MIM:228960]

     From NCBI Gene: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. Bradykinin also functions as an antimicrobial peptide with antibacterial and antifungal activity. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2014] From UniProt: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • AhR
  • PPAR-alpha
  • C/EBPbeta
  • FOXO1a
  • FOXO1

Tissue specificity:

Secreted in plasma. T-kinin is detected in malignant ovarian, colon and breast carcinomas, but not in benign tumors.

Gene Pathways:

  • Signal Transduction
  • Hemostasis
  • Complement and coagulation cascades

Molecular Function:

  • Cysteine-Type Endopeptidase Inhibitor Activity
  • Heparin Binding
  • Receptor Binding
  • Zinc Ion Binding

Biological Processes:

  • Blood Coagulation, Intrinsic Pathway
  • Inflammatory Response
  • Negative Regulation Of Blood Coagulation
  • Negative Regulation Of Cell Adhesion
  • Negative Regulation Of Proteolysis
  • Platelet Degranulation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Cytosolic Calcium Ion Concentration
  • Vasodilation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| BDK| bradykinin| major acute phase protein| A306_05783| alpha-1-MAP| alpha-2-thiol proteinase inhibitor| AS27_14126| AS28_05391| BK| EGK_12191| fb64g01| fitzgerald factor| GW7_17201| H920_05366| high molecular weight kininogen| H-kininigen| HMWK| I79_016096| kininogen| kininogen-1| kininogen 1, variant 1| kininogen 2| kininogen-2| kininogen I| kininogen II| KINKG| KINKH| KINT1G| K-kininogen| K-kininogen, differential splicing leads to HMW Kngk| KNG| Kng1_v1| KNG2| Kngk| Kngt| Kngt1| Kng_v1| L-kininogen| LMW T-kininogen I| low molecular weight kininogen| M91_05080| M959_04579| Map1| MDA_GLEAN10001562| N300_13401| N301_07747| N302_03737| N303_10301| N305_01840| N306_05840| N307_05276| N308_11015| N309_07984| N310_02227| N311_08829| N312_04404| N320_12231| N322_13420| N325_06428| N326_11907| N328_02740| N329_01820| N330_05468| N331_11691| N332_14788| N333_07222| N334_07288| N335_02496| N336_11316| N340_11784| N341_01386| PAL_GLEAN10018223| PANDA_002800| thiol proteinase inhibitor| thiostatin| Tkg| TKG6| T-kininogen 1| T-kininogen I| TREES_T100022053| williams-Fitzgerald-Flaujeac factor| Y956_07115| Z169_03279| kng1

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