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  3. KMT2D

KMT2D (Lysine methyltransferase 2D)

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The Function of KMT2D

Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription.

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Protein names

Recommended name:

Histone-lysine N-methyltransferase 2D

Alternative name(s):

Lysine N-methyltransferase 2D
ALL1-related protein
Myeloid/lymphoid or mixed-lineage leukemia protein 2

KMT2D SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10875912 (KMT2D) ??

Top Gene-Substance Interactions

KMT2D Interacts with These Diseases

Disease Score

Substances That Increase KMT2D

Substances Interaction Organism Category

Substances That Decrease KMT2D

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

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