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  3. KLF6

KLF6 (Kruppel like factor 6)

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The Function of KLF6

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.

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Protein names

Recommended name:

Krueppel-like factor 6

Alternative name(s):

B-cell-derived protein 1
Core promoter element-binding protein
GC-rich sites-binding factor GBF
Proto-oncogene BCD1
Suppressor of tumorigenicity 12 protein
Transcription factor Zf9

KLF6 SNPs

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  1. RS17731 (KLF6) ??

Top Gene-Substance Interactions

KLF6 Interacts with These Diseases

Disease Score

Substances That Increase KLF6

Substances Interaction Organism Category

Substances That Decrease KLF6

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • p53
  • Egr-1
  • AP-1
  • c-Jun
  • STAT3
  • NF-kappaB1
  • C/EBPbeta
  • Sp1
  • Brachyury

Tissue specificity:

Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.

Molecular Function:

  • Dna Binding
  • Metal Ion Binding
  • Double-Stranded Dna Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • B Cell Differentiation
  • Positive Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
  • Cellular Response To Cycloheximide
  • Cellular Response To Hydrogen Peroxide
  • Cellular Response To Peptide
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Wound Healing
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| PAC1| Anapl_07643| AS27_06939| AS28_03976| bcd1| B-cell-derived protein 1| C86813| CB1_000294041| cba1| copeb| core promoter element binding protein| core promoter element-binding protein| cpbp| FM2| FM6| GBF| GC-rich binding factor| GC-rich sites-binding factor GBF| Ierepo1| Ierepo3| immediate early response, erythropoietin 1| klf6-a| klf6-b| Krueppel-like factor 6| Krueppel-like factor 6-like| Krueppel-like factor 7| Kruppel-like factor 6| Kruppel-like zinc finger protein Zf9| M91_01956| M959_03695| MDA_GLEAN10016415| N300_13616| N301_13483| N302_03995| N303_03824| N305_14493| N306_00708| N307_00582| N308_06795| N309_01017| N312_07173| N320_02403| N321_14125| N322_09693| N324_04458| N325_02508| N326_01608| N327_05534| N328_08868| N329_08139| N330_10147| N331_09768| N332_08191| N334_00881| N335_03384| N336_10967| N339_05665| N340_06919| N341_10990| PAL_GLEAN10001872| PANDA_010138| proto-oncogene BCD1| protooncogene B-cell derived 1| R75280| ST12| suppression of tumorigenicity 12 (prostate)| suppressor of tumorigenicity 12 protein| transcription factor Zf9| TREES_T100002459| UY3_01646| Y1Q_021247| Y956_00134| Z169_13519| zf9| klf6

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