The Function of KLF6
Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
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Protein names
Recommended name:
Krueppel-like factor 6Alternative name(s):
B-cell-derived protein 1Core promoter element-binding protein
GC-rich sites-binding factor GBF
Proto-oncogene BCD1
Suppressor of tumorigenicity 12 protein
Transcription factor Zf9
- RS17731 (KLF6) ??
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Top Gene-Substance Interactions
KLF6 Interacts with These Diseases
| Disease | Score |
Substances That Increase KLF6
| Substances | Interaction | Organism | Category |
Substances That Decrease KLF6
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in placenta followed by spleen, thymus, prostate, testis, small intestine and colon. Weakly expressed in pancreas, lung, liver, heart and skeletal muscle. Also expressed in fetal brain, spleen and thymus.
Molecular Function:
- Dna Binding
- Double-Stranded Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Metal Ion Binding
Biological Processes:
- Transcription, Dna-Templated
- B Cell Differentiation
- Wound Healing
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Cycloheximide
- Cellular Response To Peptide