The Function of KLF4
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
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Protein names
Recommended name:
Krueppel-like factor 4Alternative name(s):
Epithelial zinc finger protein EZFGut-enriched krueppel-like factor
Top Gene-Substance Interactions
KLF4 Interacts with These Diseases
| Disease | Score |
Substances That Increase KLF4
| Substances | Interaction | Organism | Category |
Substances That Decrease KLF4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Molecular Function:
- Core Promoter Binding
- Core Promoter Proximal Region Sequence-Specific Dna Binding
- Phosphatidylinositol 3-Kinase Regulator Activity
- Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding Transcription Factor Recruiting
- Transcription Regulatory Region Dna Binding
- Zinc Ion Binding
Biological Processes:
- Canonical Wnt Signaling Pathway
- Cellular Response To Cycloheximide
- Cellular Response To Growth Factor Stimulus
- Cellular Response To Hydrogen Peroxide
- Cellular Response To Laminar Fluid Shear Stress
- Cellular Response To Peptide
- Cellular Response To Retinoic Acid
- Epidermal Cell Differentiation
- Epidermis Morphogenesis
- Fat Cell Differentiation
- Mesodermal Cell Fate Determination
- Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Negative Regulation Of Erk1 And Erk2 Cascade
- Negative Regulation Of Gene Expression
- Negative Regulation Of Heterotypic Cell-Cell Adhesion
- Negative Regulation Of Inflammatory Response
- Negative Regulation Of Interleukin-8 Biosynthetic Process
- Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
- Negative Regulation Of Muscle Hyperplasia
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Negative Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Negative Regulation Of Protein Kinase B Signaling
- Negative Regulation Of Response To Cytokine Stimulus
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Cellular Protein Metabolic Process
- Positive Regulation Of Gene Expression
- Positive Regulation Of Hemoglobin Biosynthetic Process
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Positive Regulation Of Protein Metabolic Process
- Positive Regulation Of Telomerase Activity
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transcription Regulatory Region Dna Binding
- Post-Embryonic Camera-Type Eye Development
- Post-Embryonic Hemopoiesis
- Regulation Of Axon Regeneration
- Regulation Of Cell Differentiation
- Somatic Stem Cell Population Maintenance
- Stem Cell Population Maintenance
- Transcription From Rna Polymerase Ii Promoter