The Function of KLF4
Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription.
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Protein names
Recommended name:
Krueppel-like factor 4Alternative name(s):
Epithelial zinc finger protein EZFGut-enriched krueppel-like factor
Top Gene-Substance Interactions
KLF4 Interacts with These Diseases
| Disease | Score |
Substances That Increase KLF4
| Substances | Interaction | Organism | Category |
Substances That Decrease KLF4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Molecular Function:
- Core Promoter Proximal Region Sequence-Specific Dna Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding Transcription Factor Recruiting
- Core Promoter Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Rna Polymerase Ii Transcription Factor Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Factor Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Zinc Ion Binding
- Phosphatidylinositol 3-Kinase Regulator Activity
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Transcription From Rna Polymerase Ii Promoter
- Mesodermal Cell Fate Determination
- Negative Regulation Of Cell Proliferation
- Epidermal Cell Differentiation
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Negative Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Negative Regulation Of Muscle Hyperplasia
- Stem Cell Population Maintenance
- Post-Embryonic Camera-Type Eye Development
- Negative Regulation Of Nf-Kappab Transcription Factor Activity
- Positive Regulation Of Cellular Protein Metabolic Process
- Negative Regulation Of Heterotypic Cell-Cell Adhesion
- Somatic Stem Cell Population Maintenance
- Post-Embryonic Hemopoiesis
- Negative Regulation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process
- Negative Regulation Of Interleukin-8 Biosynthetic Process
- Positive Regulation Of Nitric Oxide Biosynthetic Process
- Fat Cell Differentiation
- Regulation Of Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Hemoglobin Biosynthetic Process
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Regulation Of Axon Regeneration
- Epidermis Morphogenesis
- Negative Regulation Of Inflammatory Response
- Positive Regulation Of Protein Metabolic Process
- Negative Regulation Of Protein Kinase B Signaling
- Positive Regulation Of Telomerase Activity
- Canonical Wnt Signaling Pathway
- Negative Regulation Of Response To Cytokine Stimulus
- Cellular Response To Hydrogen Peroxide
- Negative Regulation Of Erk1 And Erk2 Cascade
- Cellular Response To Retinoic Acid
- Cellular Response To Growth Factor Stimulus
- Cellular Response To Cycloheximide
- Cellular Response To Laminar Fluid Shear Stress
- Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
- Cellular Response To Peptide
- Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell
- Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
- Positive Regulation Of Transcription Regulatory Region Dna Binding