The Function of KLF15
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CTGF expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Protein names
Recommended name:
Krueppel-like factor 15Alternative name(s):
Kidney-enriched krueppel-like factorTop Gene-Substance Interactions
KLF15 Interacts with These Diseases
| Disease | Score |
Substances That Increase KLF15
| Substances | Interaction | Organism | Category |
Substances That Decrease KLF15
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in liver, skeletal muscle, and kidney. Expressed in cardiomyocytes. Expression is highly reduced in cardiac tissue of patients with non-ischemic cardiomyopathy and aortic aneurysm, and in glomerular disease. Not expressed in bone marrow or lymphoid tissues.
Induction:
In podocytes, up-regulated by retinoic acid.
Molecular Function:
- Metal Ion Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Core Promoter Proximal Region Sequence-Specific Binding
- Transcription Regulatory Region Dna Binding
Biological Processes:
- Cardiac Muscle Hypertrophy In Response To Stress
- Cellular Response To Peptide
- Glial Cell Differentiation
- Glomerular Visceral Epithelial Cell Differentiation
- Glucose Transport
- Negative Regulation Of Peptidyl-Lysine Acetylation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter