The Function of KCNQ4
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
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Protein names
Recommended name:
Potassium voltage-gated channel subfamily KQT member 4Alternative name(s):
KQT-like 4Potassium channel subunit alpha KvLQT4
Voltage-gated potassium channel subunit Kv7.4
- RS4660456 (KCNQ4) ??
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Top Gene-Substance Interactions
Substances That Increase KCNQ4
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Substances That Decrease KCNQ4
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
Gene Pathways:
Molecular Function:
Biological Processes:
- Inner Ear Morphogenesis
- Potassium Ion Transport
- Sensory Perception Of Sound
- Negative Regulation Of Synaptic Transmission, Dopaminergic