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  3. KCNQ4

KCNQ4 (Potassium voltage-gated channel subfamily Q member 4)

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The Function of KCNQ4

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.

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Protein names

Recommended name:

Potassium voltage-gated channel subfamily KQT member 4

Alternative name(s):

KQT-like 4
Potassium channel subunit alpha KvLQT4
Voltage-gated potassium channel subunit Kv7.4

KCNQ4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS4660456 (KCNQ4) ??

Top Gene-Substance Interactions

Substances That Increase KCNQ4

Substances Interaction Organism Category

Substances That Decrease KCNQ4

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • CUTL1
  • PPAR-gamma2
  • PPAR-alpha
  • XBP-1
  • IRF-2
  • Olf-1
  • TGIF

Tissue specificity:

Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.

Gene Pathways:

  • Neuronal System

Molecular Function:

  • Delayed Rectifier Potassium Channel Activity
  • Potassium Channel Activity

Biological Processes:

  • Inner Ear Morphogenesis
  • Potassium Ion Transport
  • Sensory Perception Of Sound
  • Negative Regulation Of Synaptic Transmission, Dopaminergic

Drug Bank:

  • Ezogabine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_09185| AS27_13880| AS28_07972| CB1_000160008| DFNA2| DFNA2A| KQT-like 4| k(v)7.4| kv7.4| M91_07861| M959_12742| MDA_GLEAN10014323| N300_15450| N301_02895| N302_13993| N303_12702| N307_14638| N320_08716| outward rectifier channel| PAL_GLEAN10004373| PANDA_019039| potassium channel KQT-like 4| potassium channel subunit alpha KvLQT4| potassium channel voltage-gated KQ-subfamily member 4| potassium channel, voltage gated KQT-like subfamily Q, member 4| potassium channel, voltage-gated KQT-like subfamily Q, member 4| potassium voltage-gated channel KQT-like protein 4| potassium voltage-gated channel, KQT-like subfamily, member 4| potassium voltage-gated channel subfamily KQT member 4| potassium voltage-gated channel subfamily KQT member 4-like protein| Potassium voltage-gated channel subfamily KQT member 5| potassium voltage-gated channel, subfamily Q, member 4| TREES_T100018146| voltage-gated potassium channel subunit Kv7.4| Y956_14995| Z169_05321| kcnq4

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