The Function of KCNJ2
Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Inward rectifier potassium channel 2Short name:
IRK-1Alternative name(s):
Cardiac inward rectifier potassium channelInward rectifier K(+
hIRK1
Potassium channel, inwardly rectifying subfamily J member 2
- RS236586 (KCNJ2) ??
- RS72863877 (KCNJ2) ??
- RS8079702 (KCNJ2) ??
- RS8080944 (KCNJ2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
KCNJ2 Interacts with These Diseases
| Disease | Score |
Substances That Increase KCNJ2
| Substances | Interaction | Organism | Category |
Substances That Decrease KCNJ2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.
Gene Pathways:
Molecular Function:
- G-Protein Activated Inward Rectifier Potassium Channel Activity
- Inward Rectifier Potassium Channel Activity
- Phosphatidylinositol-4,5-Bisphosphate Binding
- Voltage-Gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
Biological Processes:
- Cardiac Conduction
- Cardiac Muscle Cell Action Potential Involved In Contraction
- Cellular Potassium Ion Homeostasis
- Cellular Response To Mechanical Stimulus
- Magnesium Ion Transport
- Membrane Depolarization During Cardiac Muscle Cell Action Potential
- Membrane Repolarization During Action Potential
- Membrane Repolarization During Cardiac Muscle Cell Action Potential
- Positive Regulation Of Potassium Ion Transmembrane Transport
- Potassium Ion Import
- Potassium Ion Transmembrane Transport
- Potassium Ion Transport
- Protein Homotetramerization
- Regulation Of Cardiac Muscle Cell Contraction
- Regulation Of Heart Rate By Cardiac Conduction
- Regulation Of Membrane Repolarization
- Regulation Of Resting Membrane Potential
- Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential
- Relaxation Of Cardiac Muscle
- Relaxation Of Skeletal Muscle