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  3. KCNJ2

KCNJ2 (Potassium voltage-gated channel subfamily J member 2)

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The Function of KCNJ2

Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium.

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Protein names

Recommended name:

Inward rectifier potassium channel 2

Short name:

IRK-1

Alternative name(s):

Cardiac inward rectifier potassium channel
Inward rectifier K(+
hIRK1
Potassium channel, inwardly rectifying subfamily J member 2

KCNJ2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS236586 (KCNJ2) ??
  2. RS72863877 (KCNJ2) ??
  3. RS8079702 (KCNJ2) ??
  4. RS8080944 (KCNJ2) ??

Top Gene-Substance Interactions

KCNJ2 Interacts with These Diseases

Disease Score

Substances That Increase KCNJ2

Substances Interaction Organism Category

Substances That Decrease KCNJ2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha

Tissue specificity:

Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain.

Gene Pathways:

  • Gastric acid secretion
  • Neuronal System

Molecular Function:

  • G-Protein Activated Inward Rectifier Potassium Channel Activity
  • Inward Rectifier Potassium Channel Activity
  • Phosphatidylinositol-4,5-Bisphosphate Binding
  • Voltage-Gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization

Biological Processes:

  • Cardiac Conduction
  • Cardiac Muscle Cell Action Potential Involved In Contraction
  • Cellular Potassium Ion Homeostasis
  • Cellular Response To Mechanical Stimulus
  • Magnesium Ion Transport
  • Membrane Depolarization During Cardiac Muscle Cell Action Potential
  • Membrane Repolarization During Action Potential
  • Membrane Repolarization During Cardiac Muscle Cell Action Potential
  • Positive Regulation Of Potassium Ion Transmembrane Transport
  • Potassium Ion Import
  • Potassium Ion Transmembrane Transport
  • Potassium Ion Transport
  • Protein Homotetramerization
  • Regulation Of Cardiac Muscle Cell Contraction
  • Regulation Of Heart Rate By Cardiac Conduction
  • Regulation Of Membrane Repolarization
  • Regulation Of Resting Membrane Potential
  • Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential
  • Relaxation Of Cardiac Muscle
  • Relaxation Of Skeletal Muscle
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| hIRK1| Anapl_11491| AS27_15191| AS28_13779| ATFB9| BIK| cardiac inward rectifier KIR2.1| cardiac inward rectifier potassium channel| CB1_033709003| EGK_08925| GW7_01542| H920_12290| HHBIRK1| HHIRK1| inwardly rectifying potassium channel Kir2.1| inwardly-rectifying potassium channel Kir2.1| inward rectifier channel Kir 2.1| inward rectifier channel protein| inward rectifier K(+) channel Kir2.1| inward rectifier K+ channel KIR2.1| inward rectifier potassium channel 2| inward rectifier potassium channel 2-like protein| inward rectifier potassium channel cIRK1| inward rectifier potassium channel Kir2.1| IRK1| IRK-1| Kcnf1| kir2.1| LQT7| MDA_GLEAN10015888| N300_05039| N301_08046| N302_09317| N303_03339| N306_11333| N307_13002| N308_10397| N309_05588| N310_09504| N312_13395| N320_02311| N321_04954| N324_11653| N325_12395| N326_12164| N327_03863| N328_08467| N329_01963| N330_03281| N331_12102| N333_05570| N334_05624| N336_08557| N339_06730| N340_14405| PAL_GLEAN10014811| PANDA_013574| potassium channel, inwardly rectifying subfamily J member 2| potassium channel, inwardly rectifying subfamily J, member 2| potassium inwardly-rectifying channel J2| potassium inwardly-rectifying channel subfamily J member 2| potassium inwardly-rectifying channel, subfamily J, member 2| RBL-IRK1| SQT3| TREES_T100001080| UY3_03493| Y956_08457| Z169_03780| kcnj2

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