The Function of KAT5
Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity (PubMed:17360565).
Protein names
Recommended name:
Histone acetyltransferase KAT5Alternative name(s):
60 kDa Tat-interactive proteinTip60
Histone acetyltransferase HTATIP
HIV-1 Tat interactive protein
Lysine acetyltransferase 5
cPLA(2
Top Gene-Substance Interactions
Substances That Increase KAT5
| Substances | Interaction | Organism | Category |
Substances That Decrease KAT5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Molecular Function:
- Transcription Coactivator Activity
- Histone Acetyltransferase Activity
- Acetyltransferase Activity
- Metal Ion Binding
- Androgen Receptor Binding
- Repressing Transcription Factor Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Dna Double-Strand Break Processing
- Dna Synthesis Involved In Dna Repair
- Strand Displacement
- Dna Replication
- Double-Strand Break Repair
- Double-Strand Break Repair Via Nonhomologous End Joining
- Transcription, Dna-Templated
- Dna Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator
- Response To Ionizing Radiation
- Viral Process
- Histone Acetylation
- Androgen Receptor Signaling Pathway
- Negative Regulation Of Interleukin-2 Production
- Regulation Of Growth
- Proteasome-Mediated Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Cellular Response To Estradiol Stimulus
- Regulation Of Signal Transduction By P53 Class Mediator
- Positive Regulation Of Protein Acetylation
- Beta-Catenin-Tcf Complex Assembly