The Function of JUP
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Protein names
Recommended name:
Junction plakoglobinAlternative name(s):
Catenin gammaDesmoplakin III
Desmoplakin-3
- RS191392302 (JUP) ??
- RS6503659 (JUP) ??
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Top Gene-Substance Interactions
JUP Interacts with These Diseases
| Disease | Score |
Substances That Increase JUP
| Substances | Interaction | Organism | Category |
Substances That Decrease JUP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Transcription Coactivator Activity
- Signal Transducer Activity
- Structural Molecule Activity
- Structural Constituent Of Cell Wall
- Protein Phosphatase Binding
- Protein Homodimerization Activity
- Alpha-Catenin Binding
- Cadherin Binding
- Cell Adhesion Molecule Binding
- Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- Desmosome Assembly
- Cytoskeletal Anchoring At Plasma Membrane
- Single Organismal Cell-Cell Adhesion
- Adherens Junction Organization
- Adherens Junction Assembly
- Regulation Of Cell Proliferation
- Positive Regulation Of Protein Import Into Nucleus
- Skin Development
- Detection Of Mechanical Stimulus
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Protein Heterooligomerization
- Endothelial Cell-Cell Adhesion
- Cellular Response To Indole-3-Methanol
- Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
- Regulation Of Heart Rate By Cardiac Conduction
- Establishment Of Protein Localization To Plasma Membrane
- Positive Regulation Of Canonical Wnt Signaling Pathway
- Regulation Of Ventricular Cardiac Muscle Cell Action Potential