• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. JUP

JUP (Junction plakoglobin)

Loading...

The Function of JUP

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.

0 users want this gene increased, 0 users want it decreased

Protein names

Recommended name:

Junction plakoglobin

Alternative name(s):

Catenin gamma
Desmoplakin III
Desmoplakin-3

JUP SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS191392302 (JUP) ??
  2. RS6503659 (JUP) ??

Top Gene-Substance Interactions

JUP Interacts with These Diseases

Disease Score

Substances That Increase JUP

Substances Interaction Organism Category

Substances That Decrease JUP

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • p53
  • HNF-4alpha1
  • c-Fos
  • AREB6

Gene Pathways:

  • Pathways in cancer
  • Signal Transduction
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Cell-Cell communication
  • Acute myeloid leukemia

Molecular Function:

  • Alpha-Catenin Binding
  • Cadherin Binding
  • Cadherin Binding Involved In Cell-Cell Adhesion
  • Cell Adhesion Molecule Binding
  • Cell Adhesive Protein Binding Involved In Bundle Of His Cell-Purkinje Myocyte Communication
  • Protein Homodimerization Activity
  • Protein Phosphatase Binding
  • Signal Transducer Activity
  • Structural Constituent Of Cell Wall
  • Structural Molecule Activity
  • Transcription Coactivator Activity

Biological Processes:

  • Adherens Junction Assembly
  • Adherens Junction Organization
  • Bundle Of His Cell-Purkinje Myocyte Adhesion Involved In Cell Communication
  • Cellular Response To Indole-3-Methanol
  • Cytoskeletal Anchoring At Plasma Membrane
  • Desmosome Assembly
  • Detection Of Mechanical Stimulus
  • Endothelial Cell-Cell Adhesion
  • Establishment Of Protein Localization To Plasma Membrane
  • Positive Regulation Of Canonical Wnt Signaling Pathway
  • Positive Regulation Of Protein Import Into Nucleus
  • Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Protein Heterooligomerization
  • Regulation Of Cell Proliferation
  • Regulation Of Heart Rate By Cardiac Conduction
  • Regulation Of Ventricular Cardiac Muscle Cell Action Potential
  • Single Organismal Cell-Cell Adhesion
  • Skin Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| dp3| A306_14087| arvd12| AS27_11212| catenin (cadherin-associated protein), gamma 80kDa| Ctnng| desmoplakin 3| Desmoplakin-3| desmoplakin III| dpiii| EGK_08712| gamma-catenin| gamma-catenin (plakoglobin)| jup-a| jup-b| M91_17162| M959_15208| N300_06147| N302_08181| N305_13477| N307_05517| N308_14646| N325_02186| PAL_GLEAN10019548| PANDA_011135| PDGB| PG| pkgb| plakoglobin| UY3_02227| Y1Q_005420| Y956_09870| Z169_14920| jup

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved