The Function of JPH3
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory.
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Protein names
Recommended name:
Junctophilin-3Short name:
JP-3Alternative name(s):
Junctophilin type 3Trinucleotide repeat-containing gene 22 protein
- RS34975147 (JPH3) ??
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Top Gene-Substance Interactions
Substances That Increase JPH3
| Substances | Interaction | Organism | Category |
Substances That Decrease JPH3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Specifically expressed in brain.
Molecular Function:
Biological Processes:
- Learning
- Memory
- Exploration Behavior
- Locomotion
- Regulation Of Neuronal Synaptic Plasticity
- Neuromuscular Process Controlling Balance
- Regulation Of Ryanodine-Sensitive Calcium-Release Channel Activity
- Calcium Ion Transport Into Cytosol