The Function of JAK1
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529).
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Protein names
Recommended name:
Tyrosine-protein kinase JAK1Short name:
JAK-1Alternative name(s):
Janus kinase 1- RS11208534 (JAK1) ??
- RS17127169 (JAK1) ??
- RS2780902 (JAK1) ??
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Top Gene-Substance Interactions
Substances That Increase JAK1
| Substances | Interaction | Organism | Category |
Substances That Decrease JAK1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Cofactor:
Mn(2+) was used in the in vitro kinase assay but Mg(2+) is likely to be the in vivo cofactor.
Molecular Function:
- Atp Binding
- Growth Hormone Receptor Binding
- Metal Ion Binding
- Non-Membrane Spanning Protein Tyrosine Kinase Activity
- Protein Phosphatase Binding
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Receptor Binding
- Ubiquitin Protein Ligase Binding
Biological Processes:
- Cell Differentiation
- Innate Immune Response
- Interferon-Gamma-Mediated Signaling Pathway
- Interleukin-2-Mediated Signaling Pathway
- Intracellular Signal Transduction
- Mapk Cascade
- Peptidyl-Tyrosine Autophosphorylation
- Positive Regulation Of Sprouting Angiogenesis
- Protein Phosphorylation
- Regulation Of Cell Proliferation
- Regulation Of Interferon-Gamma-Mediated Signaling Pathway
- Regulation Of Type I Interferon-Mediated Signaling Pathway
- Response To Antibiotic
- Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
- Type I Interferon Signaling Pathway
Drug Bank:
- Ruxolitinib
- Tofacitinib