The Function of IVNS1ABP
Plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization; Protects neurons from dendritic spines and actin filaments damage induced by the actin-destabilizing cytochalasin B when overexpressed. Activates Erk signaling pathway when overexpressed in cultured cell lines (By similarity). May be a component of the cellular splicing machinery with a role in pre-mRNA splicing; may mediate the inhibition of splicing by NS/influenza virus NS1A protein. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription.
Protein names
Recommended name:
Influenza virus NS1A-binding proteinShort name:
NS1-BPAlternative name(s):
NS1-binding proteinAryl hydrocarbon receptor-associated protein 3
Top Gene-Substance Interactions
IVNS1ABP Interacts with These Diseases
| Disease | Score |
Substances That Increase IVNS1ABP
| Substances | Interaction | Organism | Category |
Substances That Decrease IVNS1ABP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Biological Processes:
- Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
- Response To Virus
- Rna Splicing
- Transcription From Rna Polymerase Iii Promoter