The Function of ITPR1
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
Protein names
Recommended name:
Inositol 1,4,5-trisphosphate receptor type 1Short name:
IP3R 1Alternative name(s):
IP3 receptor isoform 1InsP3R1
Type 1 inositol 1,4,5-trisphosphate receptor
Type 1 InsP3 receptor
- RS17041333 (ITPR1) ??
- RS2322734 (ITPR1) ??
- RS304029 (ITPR1) ??
- RS6762644 (ITPR1) ??
- RS72622154 (ITPR1) ??
- RS7632000 (ITPR1) ??
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Top Gene-Substance Interactions
ITPR1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ITPR1
| Substances | Interaction | Organism | Category |
Substances That Decrease ITPR1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Widely expressed.
Gene Pathways:
- Metabolism
- Disease
- Immune System
- Signal Transduction
- Calcium signaling pathway
- Hemostasis
- Pancreatic secretion
- Vascular smooth muscle contraction
- Alzheimer's disease
- Phosphatidylinositol signaling system
- Gastric acid secretion
- Glutamatergic synapse
- Long-term depression
- Oocyte meiosis
- GnRH signaling pathway
- Salivary secretion
- Huntington's disease
- Long-term potentiation
- Phototransduction - fly
Caution:
Alternative splice sites (AA 1053-1054) represent a non-canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow.
Molecular Function:
- Calcium Channel Inhibitor Activity
- Calcium Ion Binding
- Calcium Ion Transmembrane Transporter Activity
- Calcium-Release Channel Activity
- Inositol 1,4,5 Trisphosphate Binding
- Inositol 1,4,5-Trisphosphate-Sensitive Calcium-Release Channel Activity
- Phosphatidylinositol Binding
Biological Processes:
- Calcium Ion Transport
- Endoplasmic Reticulum Calcium Ion Homeostasis
- Epithelial Fluid Transport
- Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
- Negative Regulation Of Calcium-Mediated Signaling
- Platelet Activation
- Post-Embryonic Development
- Regulation Of Autophagy
- Regulation Of Cardiac Conduction
- Regulation Of Insulin Secretion
- Release Of Sequestered Calcium Ion Into Cytosol
- Response To Hypoxia
- Signal Transduction
- Voluntary Musculoskeletal Movement