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  3. ITPR1

ITPR1 (Inositol 1,4,5-trisphosphate receptor type 1)

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The Function of ITPR1

Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.

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Protein names

Recommended name:

Inositol 1,4,5-trisphosphate receptor type 1

Short name:

IP3R 1

Alternative name(s):

IP3 receptor isoform 1
InsP3R1
Type 1 inositol 1,4,5-trisphosphate receptor
Type 1 InsP3 receptor

ITPR1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17041333 (ITPR1) ??
  2. RS2322734 (ITPR1) ??
  3. RS304029 (ITPR1) ??
  4. RS6762644 (ITPR1) ??
  5. RS72622154 (ITPR1) ??
  6. RS7632000 (ITPR1) ??

Top Gene-Substance Interactions

ITPR1 Interacts with These Diseases

Disease Score

Substances That Increase ITPR1

Substances Interaction Organism Category

Substances That Decrease ITPR1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • NF-kappaB1
  • c-Myb

Tissue specificity:

Widely expressed.

Gene Pathways:

  • Metabolism
  • Disease
  • Immune System
  • Signal Transduction
  • Calcium signaling pathway
  • Hemostasis
  • Pancreatic secretion
  • Vascular smooth muscle contraction
  • Alzheimer's disease
  • Phosphatidylinositol signaling system
  • Gastric acid secretion
  • Glutamatergic synapse
  • Long-term depression
  • Oocyte meiosis
  • GnRH signaling pathway
  • Salivary secretion
  • Huntington's disease
  • Long-term potentiation
  • Phototransduction - fly

Caution:

Alternative splice sites (AA 1053-1054) represent a non-canonical GA-AG donor-acceptor pair, but are well-supported by all available human transcripts, and by homologous transcripts in mouse, rat and cow.

Molecular Function:

  • Calcium Channel Inhibitor Activity
  • Calcium Ion Binding
  • Calcium Ion Transmembrane Transporter Activity
  • Calcium-Release Channel Activity
  • Inositol 1,4,5 Trisphosphate Binding
  • Inositol 1,4,5-Trisphosphate-Sensitive Calcium-Release Channel Activity
  • Phosphatidylinositol Binding

Biological Processes:

  • Calcium Ion Transport
  • Endoplasmic Reticulum Calcium Ion Homeostasis
  • Epithelial Fluid Transport
  • Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
  • Negative Regulation Of Calcium-Mediated Signaling
  • Platelet Activation
  • Post-Embryonic Development
  • Regulation Of Autophagy
  • Regulation Of Cardiac Conduction
  • Regulation Of Insulin Secretion
  • Release Of Sequestered Calcium Ion Into Cytosol
  • Response To Hypoxia
  • Signal Transduction
  • Voluntary Musculoskeletal Movement

Drug Bank:

  • Caffeine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| ACV| CB1_000828002| CLA4| D6Pas2| ENSMUSG00000072853| GB11927| H920_17056| I145TR| I79_004653| inositol 1,4,5-triphosphate receptor| inositol 1,4,5-triphosphate receptor 1| inositol 1,4,5-triphosphate receptor-I| inositol 1,4,5-triphosphate receptor, type 1| inositol 1,4,5-trisphosphate-binding protein P400| inositol 1,4,5,-tris-phosphate receptor| inositol 1,4,5-trisphosphate receptor 1| inositol 1,4,5-trisphosphate receptor, type 1| Inositol 1,4,5-trisphosphate receptor type 1-like protein| Inositol 1,4,5-trisphosphate receptor type 2 isoform 6-like protein| inositol trisphosphate receptor type1| InsP3R| insP3R1| InsP>3<R type I| InsP3R type I| Ip3r| IP-3-R| IP3R1| IP3R 1| IP3 receptor| Itpr-1| MDA_GLEAN10023249| N300_04391| N305_14736| N306_02092| N308_15494| N324_08499| N329_06469| N333_13397| N335_05706| opisthotonus| opt| P400| PAL_GLEAN10009282| Pcp1| Pcp-1| PPP1R94| protein PCD-6| protein phosphatase 1, regulatory subunit 94| Purkinje cell protein 1| SCA15| SCA16| SCA29| TREES_T100007091| type 1 inositol 1,4,5-trisphosphate receptor| type 1 InsP3 receptor| type I inositol triphosphate receptor| UY3_08442| wblo| xip3r| Y1Q_030704| Z169_04880| itpr1

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