Summary of ITLN1
The gene codes for a protein, intelectin 1. It is on chromosome 1 [R].
The Function of ITLN1
Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.
Protein names
Recommended name:
Intelectin-1Short name:
ITLN-1Alternative name(s):
Endothelial lectin HL-1Galactofuranose-binding lectin
Intestinal lactoferrin receptor
Omentin
- RS2274910 (ITLN1) ??
- RS2297559 (ITLN1) ??
- RS4656958 (ITLN1) ??
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Top Gene-Substance Interactions
ITLN1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ITLN1
| Substances | Interaction | Organism | Category |
Substances That Decrease ITLN1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.
Developmental stage:
Found in fetal small intestine and thymus.
Molecular Function:
Biological Processes:
- Positive Regulation Of Glucose Import
- Positive Regulation Of Protein Phosphorylation
- Response To Nematode