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  3. ITLN1

ITLN1 (Intelectin 1)

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Summary of ITLN1

The gene codes for a protein, intelectin 1. It is on chromosome 1 [R].

0 users want this gene increased, 0 users want it decreased

The Function of ITLN1

Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism.

Protein names

Recommended name:

Intelectin-1

Short name:

ITLN-1

Alternative name(s):

Endothelial lectin HL-1
Galactofuranose-binding lectin
Intestinal lactoferrin receptor
Omentin

ITLN1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2274910 (ITLN1) ??
  2. RS2297559 (ITLN1) ??
  3. RS4656958 (ITLN1) ??

Top Gene-Substance Interactions

ITLN1 Interacts with These Diseases

Disease Score

Substances That Increase ITLN1

Substances Interaction Organism Category

Substances That Decrease ITLN1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CUTL1
  • Pbx1a
  • Pax-6
  • MRF-2
  • Tal-1beta
  • Bach1
  • E47
  • Hand1

Tissue specificity:

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.

Developmental stage:

Found in fetal small intestine and thymus.

Molecular Function:

  • Carbohydrate Binding

Biological Processes:

  • Positive Regulation Of Glucose Import
  • Positive Regulation Of Protein Phosphorylation
  • Response To Nematode
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| HL-1| calcium-dependent galactosyl-specific lectin| EGK_01516| endothelial lectin HL-1| galactofuranose-binding lectin| hIntL| hl1| intelectin-1| intelectin-1a| intelectin 1 (galactofuranose binding)| intelectin 1 (galactofuranose binding)-like| intelectin 2| intelectin 5| intelectin a| intestinal lactoferrin receptor| intl| INTL1| ITLN| ITLN-1| Itln2| Itln3| Itln5| Itlna| lactoferrin receptor| LFR| omentin| truncated intelectin 3| xeel| itln1

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