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  3. ITIH3

ITIH3 (Inter-alpha-trypsin inhibitor heavy chain 3)

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Summary of ITIH3

The gene codes for a protein, inter-alpha-trypsin inhibitor heavy chain 3. Changes are linked to an increased risk of schizophrenia and major depressive disorder [R].

0 users want this gene increased, 0 users want it decreased

The Function of ITIH3

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

Protein names

Recommended name:

Inter-alpha-trypsin inhibitor heavy chain H3

Short name:

SHAP

Alternative name(s):

ITI heavy chain H3
ITI-HC3
Inter-alpha-inhibitor heavy chain 3
Serum-derived hyaluronan-associated protein

ITIH3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17331151 (ITIH3) ??
  2. RS2240919 (ITIH3) ??
  3. RS2240920 (ITIH3) ??
  4. RS2535627 (ITIH3) ??
  5. RS2535629 (ITIH3) ??
  6. RS4687552 (ITIH3) ??
  7. RS736408 (ITIH3) ??

Top Gene-Substance Interactions

Substances That Increase ITIH3

Substances Interaction Organism Category

Substances That Decrease ITIH3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2
  • AhR
  • Arnt
  • PPAR-alpha
  • ARP-1
  • c-Myc
  • c-Rel

Molecular Function:

  • Endopeptidase Inhibitor Activity
  • Serine-Type Endopeptidase Inhibitor Activity

Biological Processes:

  • Hyaluronan Metabolic Process
  • Platelet Degranulation
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| serum-derived hyaluronan-associated protein| SHAP| A306_06381| CB1_001347006| GW7_01618| h3p| H920_13392| inter-alpha (globulin) inhibitor H3| inter-alpha (globulin) inhibitor, H3 polypeptide| inter-alpha inhibitor H3| inter-alpha-inhibitor H3 chain| inter-alpha-inhibitor heavy chain 3| inter-alpha trypsin inhibitor, heavy chain 3| inter-alpha-trypsin inhibitor heavy chain3| inter-alpha-trypsin inhibitor heavy chain H3| Intin3| Itih-3| ITI-HC3| ITI heavy chain H3| N309_02482| N310_11366| N311_11978| N320_12104| N322_09093| N324_06872| N329_09517| N335_03706| N336_09542| N339_10952| N341_05069| PAIHC3| PAL_GLEAN10022216| PANDA_007565| pre-alpha (globulin) inhibitor, H3 polypeptide| pre-alpha-inhibitor, heavy chain 3| TREES_T100010294| UY3_03037| itih3

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