The Function of ITGB1
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).
Protein names
Recommended name:
Integrin beta-1Short name:
GPIIAAlternative name(s):
Fibronectin receptor subunit betaGlycoprotein IIa
VLA-4 subunit beta
CD antigen CD29
Top Gene-Substance Interactions
ITGB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ITGB1
| Substances | Interaction | Organism | Category |
Substances That Decrease ITGB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
Gene Pathways:
- Cell-Cell communication
- Immune System
- Hemostasis
- Small cell lung cancer
- Pathogenic Escherichia coli infection
- Shigellosis
- Toxoplasmosis
- Pathways in cancer
- Bacterial invasion of epithelial cells
- Leishmaniasis
- Cell adhesion molecules (CAMs)
- Hypertrophic cardiomyopathy (HCM)
- Dilated cardiomyopathy
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
- Leukocyte transendothelial migration
- Axon guidance
- Regulation of actin cytoskeleton
- Extracellular matrix organization
- Phagosome
Molecular Function:
- Actin Binding
- Cadherin Binding Involved In Cell-Cell Adhesion
- Cell Adhesion Molecule Binding
- Collagen Binding Involved In Cell-Matrix Adhesion
- Coreceptor Activity
- Fibronectin Binding
- Metal Ion Binding
- Protease Binding
- Protein Complex Binding
- Protein Heterodimerization Activity
- Virus Receptor Activity
- Glycoprotein Binding
- Peptide Binding
Biological Processes:
- Axon Extension
- B Cell Differentiation
- Calcium-Independent Cell-Matrix Adhesion
- Cardiac Muscle Cell Differentiation
- Cell Adhesion Mediated By Integrin
- Cell-Cell Adhesion Mediated By Integrin
- Cell Fate Specification
- Cell-Matrix Adhesion
- Cell Migration Involved In Sprouting Angiogenesis
- Cell-Substrate Adhesion
- Cellular Defense Response
- Cellular Response To Low-Density Lipoprotein Particle Stimulus
- Dendrite Morphogenesis
- Extracellular Matrix Organization
- Formation Of Radial Glial Scaffolds
- G1/S Transition Of Mitotic Cell Cycle
- Germ Cell Migration
- Heterotypic Cell-Cell Adhesion
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Integrin-Mediated Signaling Pathway
- In Utero Embryonic Development
- Leukocyte Cell-Cell Adhesion
- Leukocyte Migration
- Leukocyte Tethering Or Rolling
- Mesodermal Cell Differentiation
- Negative Regulation Of Anoikis
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Rho Protein Signal Transduction
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Cell Proliferation
- Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
- Positive Regulation Of Gtpase Activity
- Receptor Internalization
- Regulation Of Cell Cycle
- Regulation Of Collagen Catabolic Process
- Regulation Of Immune Response
- Sarcomere Organization
- Visual Learning
- Bicellular Tight Junction Assembly
- Cellular Calcium Ion Homeostasis
- Cellular Response To Ionizing Radiation
- Cellular Response To Mechanical Stimulus
- Cellular Response To Vitamin D
- Maternal Process Involved In Female Pregnancy
- Negative Regulation Of Cell Projection Organization
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Neuron Differentiation
- Positive Regulation Of Cell Migration
- Positive Regulation Of Cell-Substrate Adhesion
- Positive Regulation Of Endocytosis
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Neuron Projection Development
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Protein Transport Within Lipid Bilayer
- Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
- Response To Gonadotropin
- Response To Transforming Growth Factor Beta
- Tissue Homeostasis
Drug Bank:
- Anti-Thymocyte Globulin (Rabbit)