The Function of ITGB1
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Acts as a receptor for cytomegalovirus/HHV-5 (PubMed:20660204). Acts as a receptor for Epstein-Barr virus/HHV-4 (PubMed:17945327). Integrin ITGA5:ITGB1 acts as a receptor for human parvovirus B19 (PubMed:12907437). Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus (PubMed:12941907). Acts as a receptor for mammalian reovirus (PubMed:16501085). In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions (PubMed:10397733).
Protein names
Recommended name:
Integrin beta-1Short name:
GPIIAAlternative name(s):
Fibronectin receptor subunit betaGlycoprotein IIa
VLA-4 subunit beta
CD antigen CD29
Top Gene-Substance Interactions
ITGB1 Interacts with These Diseases
| Disease | Score |
Substances That Increase ITGB1
| Substances | Interaction | Organism | Category |
Substances That Decrease ITGB1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 is widely expressed, other isoforms are generally coexpressed with a more restricted distribution. Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells. Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines. Isoform 4, rather than isoform 3, is selectively expressed in peripheral T-cells. Isoform 3 is expressed in non-proliferating and differentiated prostate gland epithelial cells and in platelets, on the surface of erythroleukemia cells and in various hematopoietic cell lines. Isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle).
Gene Pathways:
- Immune System
- Axon guidance
- Toxoplasmosis
- Regulation of actin cytoskeleton
- Hemostasis
- Small cell lung cancer
- Extracellular matrix organization
- Dilated cardiomyopathy
- Pathways in cancer
- Cell-Cell communication
- Pathogenic Escherichia coli infection
- Bacterial invasion of epithelial cells
- Phagosome
- Shigellosis
- Leukocyte transendothelial migration
- Hypertrophic cardiomyopathy (HCM)
- Cell adhesion molecules (CAMs)
- Leishmaniasis
- Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Molecular Function:
- Virus Receptor Activity
- Glycoprotein Binding
- Fibronectin Binding
- Protease Binding
- Actin Binding
- Coreceptor Activity
- Protein Complex Binding
- Peptide Binding
- Metal Ion Binding
- Protein Heterodimerization Activity
- Cell Adhesion Molecule Binding
- Collagen Binding Involved In Cell-Matrix Adhesion
- Cadherin Binding Involved In Cell-Cell Adhesion
Biological Processes:
- G1/S Transition Of Mitotic Cell Cycle
- In Utero Embryonic Development
- Cell Fate Specification
- Tissue Homeostasis
- Cell Migration Involved In Sprouting Angiogenesis
- Cellular Calcium Ion Homeostasis
- Cellular Defense Response
- Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
- Leukocyte Cell-Cell Adhesion
- Cell-Matrix Adhesion
- Calcium-Independent Cell-Matrix Adhesion
- Integrin-Mediated Signaling Pathway
- Regulation Of G-Protein Coupled Receptor Protein Signaling Pathway
- Positive Regulation Of Cell Proliferation
- Negative Regulation Of Cell Proliferation
- Germ Cell Migration
- Visual Learning
- Regulation Of Collagen Catabolic Process
- Positive Regulation Of Cell-Substrate Adhesion
- Positive Regulation Of Neuron Projection Development
- Formation Of Radial Glial Scaffolds
- B Cell Differentiation
- Extracellular Matrix Organization
- Positive Regulation Of Cell Migration
- Negative Regulation Of Cell Projection Organization
- Cell-Substrate Adhesion
- Receptor Internalization
- Protein Transport Within Lipid Bilayer
- Cell Adhesion Mediated By Integrin
- Cell-Cell Adhesion Mediated By Integrin
- Heterotypic Cell-Cell Adhesion
- Response To Gonadotropin
- Negative Regulation Of Rho Protein Signal Transduction
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Gtpase Activity
- Sarcomere Organization
- Negative Regulation Of Cell Differentiation
- Negative Regulation Of Neuron Differentiation
- Positive Regulation Of Endocytosis
- Mesodermal Cell Differentiation
- Axon Extension
- Dendrite Morphogenesis
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Regulation Of Immune Response
- Leukocyte Migration
- Leukocyte Tethering Or Rolling
- Regulation Of Cell Cycle
- Cardiac Muscle Cell Differentiation
- Maternal Process Involved In Female Pregnancy
- Bicellular Tight Junction Assembly
- Cellular Response To Mechanical Stimulus
- Cellular Response To Vitamin D
- Cellular Response To Low-Density Lipoprotein Particle Stimulus
- Cellular Response To Ionizing Radiation
- Response To Transforming Growth Factor Beta
- Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
- Negative Regulation Of Anoikis
Drug Bank:
- Anti-Thymocyte Globulin (Rabbit)