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  3. ITGA2

ITGA2 (Integrin subunit alpha 2)

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Summary of ITGA2

The gene codes for a protein, integrin subunit alpha 2. Without it, one may get bleeding disorder platelet-type 9 [R].

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The Function of ITGA2

(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).

Protein names

Recommended name:

Integrin alpha-2

Alternative name(s):

CD49 antigen-like family member B
Collagen receptor
Platelet membrane glycoprotein Ia
GPIa
VLA-2 subunit alpha
CD antigen CD49b

ITGA2 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1126643 (ITGA2) ??

Top Gene-Substance Interactions

ITGA2 Interacts with These Diseases

Disease Score

Substances That Increase ITGA2

Substances Interaction Organism Category

Substances That Decrease ITGA2

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Platelet-type bleeding disorder 9

     From NCBI Gene: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] From UniProt: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Max
  • Nkx2-5
  • c-Myc

Gene Pathways:

  • Pathways in cancer
  • Regulation of actin cytoskeleton
  • Hemostasis
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Extracellular matrix organization
  • Small cell lung cancer
  • Dilated cardiomyopathy
  • Hematopoietic cell lineage
  • Hypertrophic cardiomyopathy (HCM)
  • Phagosome

Molecular Function:

  • Collagen Binding
  • Collagen Binding Involved In Cell-Matrix Adhesion
  • Collagen Receptor Activity
  • Metal Ion Binding
  • Protein Complex Binding
  • Virus Receptor Activity

Biological Processes:

  • Animal Organ Morphogenesis
  • Blood Coagulation
  • Cell Adhesion
  • Cell Adhesion Mediated By Integrin
  • Cell-Matrix Adhesion
  • Cell Proliferation
  • Cell-Substrate Adhesion
  • Cellular Response To Estradiol Stimulus
  • Cellular Response To Mechanical Stimulus
  • Collagen-Activated Signaling Pathway
  • Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
  • Establishment Of Protein Localization
  • Extracellular Matrix Organization
  • Female Pregnancy
  • Focal Adhesion Assembly
  • Hepatocyte Differentiation
  • Hypotonic Response
  • Integrin-Mediated Signaling Pathway
  • Mammary Gland Development
  • Mesodermal Cell Differentiation
  • Positive Regulation Of Alkaline Phosphatase Activity
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Cell Projection Organization
  • Positive Regulation Of Collagen Binding
  • Positive Regulation Of Collagen Biosynthetic Process
  • Positive Regulation Of Dna Binding
  • Positive Regulation Of Epithelial Cell Migration
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Leukocyte Migration
  • Positive Regulation Of Phagocytosis, Engulfment
  • Positive Regulation Of Positive Chemotaxis
  • Positive Regulation Of Smooth Muscle Cell Migration
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Smooth Muscle Contraction
  • Positive Regulation Of Translation
  • Positive Regulation Of Transmission Of Nerve Impulse
  • Response To Amine
  • Response To Hypoxia
  • Response To L-Ascorbic Acid
  • Response To Muscle Activity
  • Response To Parathyroid Hormone
  • Skin Morphogenesis
  • Substrate-Dependent Cell Migration
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| alpha 2 integrin| alpha 2 subunit of VLA-2 receptor| BR| CB1_000853006| CD49 antigen-like family member B| CD49B| collagen receptor| D623_10004357| DX5| EGK_16473| GPIa| GW7_01421| HPA-5| human platelet alloantigen system 5| integrin alpha 2| Integrin alpha-2| integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)| integrin alpha-2-like protein| integrin alpha 2 subunit| M91_01426| MDA_GLEAN10023544| N309_14981| N312_11386| N320_09926| N322_09141| N325_01417| N340_03980| PAL_GLEAN10009654| PANDA_010506| platelet antigen Br| platelet glycoprotein GPIa| platelet glycoprotein Ia| Platelet membrane glycoprotein Ia| TREES_T100005285| very late activation protein 2 receptor, alpha-2 subunit| VLA-2| VLA-2 alpha chain| VLA-2 receptor, alpha 2 subunit| VLA-2 subunit alpha| VLAA2| Y1Q_026890| Y956_02300| itga2

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