Summary of ITGA2
The gene codes for a protein, integrin subunit alpha 2. Without it, one may get bleeding disorder platelet-type 9 [R].
The Function of ITGA2
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).
Protein names
Recommended name:
Integrin alpha-2Alternative name(s):
CD49 antigen-like family member BCollagen receptor
Platelet membrane glycoprotein Ia
GPIa
VLA-2 subunit alpha
CD antigen CD49b
- RS1126643 (ITGA2) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ITGA2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ITGA2
| Substances | Interaction | Organism | Category |
Substances That Decrease ITGA2
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Platelet-type bleeding disorder 9
From NCBI Gene: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] From UniProt: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Virus Receptor Activity
- Collagen Binding
- Protein Complex Binding
- Collagen Receptor Activity
- Metal Ion Binding
- Collagen Binding Involved In Cell-Matrix Adhesion
Biological Processes:
- Response To Hypoxia
- Positive Regulation Of Leukocyte Migration
- Substrate-Dependent Cell Migration
- Hypotonic Response
- Cell Adhesion
- Cell-Matrix Adhesion
- Integrin-Mediated Signaling Pathway
- Female Pregnancy
- Blood Coagulation
- Cell Proliferation
- Animal Organ Morphogenesis
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Alkaline Phosphatase Activity
- Response To Amine
- Response To Muscle Activity
- Positive Regulation Of Smooth Muscle Cell Migration
- Extracellular Matrix Organization
- Mammary Gland Development
- Positive Regulation Of Cell Projection Organization
- Cell-Substrate Adhesion
- Positive Regulation Of Collagen Biosynthetic Process
- Positive Regulation Of Collagen Binding
- Response To L-Ascorbic Acid
- Cell Adhesion Mediated By Integrin
- Collagen-Activated Signaling Pathway
- Positive Regulation Of Dna Binding
- Skin Morphogenesis
- Establishment Of Protein Localization
- Positive Regulation Of Translation
- Positive Regulation Of Cell Adhesion
- Positive Regulation Of Smooth Muscle Contraction
- Focal Adhesion Assembly
- Mesodermal Cell Differentiation
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Positive Chemotaxis
- Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
- Positive Regulation Of Transmission Of Nerve Impulse
- Positive Regulation Of Phagocytosis, Engulfment
- Hepatocyte Differentiation
- Response To Parathyroid Hormone
- Cellular Response To Mechanical Stimulus
- Cellular Response To Estradiol Stimulus