Summary of ITGA2
The gene codes for a protein, integrin subunit alpha 2. Without it, one may get bleeding disorder platelet-type 9 [R].
The Function of ITGA2
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387).
Protein names
Recommended name:
Integrin alpha-2Alternative name(s):
CD49 antigen-like family member BCollagen receptor
Platelet membrane glycoprotein Ia
GPIa
VLA-2 subunit alpha
CD antigen CD49b
- RS1126643 (ITGA2) ??
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Top Gene-Substance Interactions
ITGA2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ITGA2
| Substances | Interaction | Organism | Category |
Substances That Decrease ITGA2
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Platelet-type bleeding disorder 9
From NCBI Gene: This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] From UniProt: (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for human rotavirus A (PubMed:12941907). Integrin ITGA2:ITGB1 acts as a receptor for human echoviruses 1 and 8 (PubMed:8411387). Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Collagen Binding
- Collagen Binding Involved In Cell-Matrix Adhesion
- Collagen Receptor Activity
- Metal Ion Binding
- Protein Complex Binding
- Virus Receptor Activity
Biological Processes:
- Animal Organ Morphogenesis
- Blood Coagulation
- Cell Adhesion
- Cell Adhesion Mediated By Integrin
- Cell-Matrix Adhesion
- Cell Proliferation
- Cell-Substrate Adhesion
- Cellular Response To Estradiol Stimulus
- Cellular Response To Mechanical Stimulus
- Collagen-Activated Signaling Pathway
- Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain
- Establishment Of Protein Localization
- Extracellular Matrix Organization
- Female Pregnancy
- Focal Adhesion Assembly
- Hepatocyte Differentiation
- Hypotonic Response
- Integrin-Mediated Signaling Pathway
- Mammary Gland Development
- Mesodermal Cell Differentiation
- Positive Regulation Of Alkaline Phosphatase Activity
- Positive Regulation Of Cell Adhesion
- Positive Regulation Of Cell Projection Organization
- Positive Regulation Of Collagen Binding
- Positive Regulation Of Collagen Biosynthetic Process
- Positive Regulation Of Dna Binding
- Positive Regulation Of Epithelial Cell Migration
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Leukocyte Migration
- Positive Regulation Of Phagocytosis, Engulfment
- Positive Regulation Of Positive Chemotaxis
- Positive Regulation Of Smooth Muscle Cell Migration
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Smooth Muscle Contraction
- Positive Regulation Of Translation
- Positive Regulation Of Transmission Of Nerve Impulse
- Response To Amine
- Response To Hypoxia
- Response To L-Ascorbic Acid
- Response To Muscle Activity
- Response To Parathyroid Hormone
- Skin Morphogenesis
- Substrate-Dependent Cell Migration