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  3. IRX5

IRX5 (Iroquois homeobox 5)

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The Function of IRX5

Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.

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Protein names

Recommended name:

Iroquois-class homeodomain protein IRX-5

Alternative name(s):

Homeodomain protein IRX-2A
Homeodomain protein IRXB2
Iroquois homeobox protein 5

IRX5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS17208368 (IRX5) ??
  2. RS4622507 (IRX5) ??
  3. RS4783860 (IRX5) ??

Top Gene-Substance Interactions

IRX5 Interacts with These Diseases

Disease Score

Substances That Increase IRX5

Substances Interaction Organism Category

Substances That Decrease IRX5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Brachyury
  • ATF6

Induction:

Down-regulated by 1,25-dihydroxyvitamin D3 in prostate cancer samples from patients assigned to receive weekly high-dose 1,25-dihydroxyvitamin D3 before radical prostatectomy. Also down-regulated by 1,25-dihydroxyvitamin D3 in the human androgen-sensitive prostate cancer cell line LNCaP and in the estrogen-sensitive breast cancer cell line MCF-7.

Molecular Function:

  • Sequence-Specific Dna Binding
  • Vitamin D Binding

Biological Processes:

  • Embryonic Cranial Skeleton Morphogenesis
  • Gonad Development
  • Neuron Maturation
  • Regulation Of Heart Rate
  • Regulation Of Transcription, Dna-Templated
  • Response To Stimulus
  • Retinal Bipolar Neuron Differentiation
  • Transcription, Dna-Templated
  • Visual Perception
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| iroquois-class homeodomain protein IRX-2| A306_01634| CB1_000856003| HMMS| homeodomain protein IRX-2A| homeodomain protein IRXB2| I79_003733| iroquois-5| iroquois-class homeodomain protein irx-5| Iroquois homeobox protein 5| Iroquois related homeobox 5 (Drosophila)| iroquois-related homeobox transcription factor| IRX-2a| IRXB2| M91_16270| N303_12341| N307_05647| PAL_GLEAN10011039| TREES_T100002907| UY3_01509| Xiro5| Y1Q_021792| irx5

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