The Function of IRX5
Establishes the cardiac repolarization gradient by its repressive actions on the KCND2 potassium-channel gene. Required for retinal cone bipolar cell differentiation. May regulate contrast adaptation in the retina and control specific aspects of visual function in circuits of the mammalian retina (By similarity). Could be involved in the regulation of both the cell cycle and apoptosis in prostate cancer cells. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.
Protein names
Recommended name:
Iroquois-class homeodomain protein IRX-5Alternative name(s):
Homeodomain protein IRX-2AHomeodomain protein IRXB2
Iroquois homeobox protein 5
- RS17208368 (IRX5) ??
- RS4622507 (IRX5) ??
- RS4783860 (IRX5) ??
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Top Gene-Substance Interactions
IRX5 Interacts with These Diseases
| Disease | Score |
Substances That Increase IRX5
| Substances | Interaction | Organism | Category |
Substances That Decrease IRX5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Induction:
Down-regulated by 1,25-dihydroxyvitamin D3 in prostate cancer samples from patients assigned to receive weekly high-dose 1,25-dihydroxyvitamin D3 before radical prostatectomy. Also down-regulated by 1,25-dihydroxyvitamin D3 in the human androgen-sensitive prostate cancer cell line LNCaP and in the estrogen-sensitive breast cancer cell line MCF-7.
Molecular Function:
Biological Processes:
- Embryonic Cranial Skeleton Morphogenesis
- Gonad Development
- Neuron Maturation
- Regulation Of Heart Rate
- Regulation Of Transcription, Dna-Templated
- Response To Stimulus
- Retinal Bipolar Neuron Differentiation
- Transcription, Dna-Templated
- Visual Perception