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  3. IRF2

IRF2 (Interferon regulatory factor 2)

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The Function of IRF2

Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.

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Protein names

Recommended name:

Interferon regulatory factor 2

Short name:

IRF-2

Top Gene-Substance Interactions

Substances That Increase IRF2

Substances Interaction Organism Category

Substances That Decrease IRF2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • STAT3
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • IRF-2
  • STAT6

Tissue specificity:

Expressed throughout the epithelium of the colon. Also expressed in lamina propria.

Gene Pathways:

  • Immune System
  • Hemostasis

Induction:

By viruses and IFN.

Molecular Function:

  • Dna Binding
  • Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
  • Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Blood Coagulation
  • Cell Proliferation
  • Interferon-Gamma-Mediated Signaling Pathway
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Regulation Of Transcription, Dna-Templated
  • Type I Interferon Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Anapl_09739| AS27_13295| AS28_03518| CB1_000998005| EGK_16278| GW7_18497| H920_12497| interferon regulatory-factor 2| interferon regulatory factor 2b| interferon regulatory factor 2-like protein| interferon responsive factor 2| IRF-2| irf2b| M959_12667| MDA_GLEAN10021002| N300_04181| N301_11472| N302_04158| N303_01061| N305_05839| N306_10082| N307_08266| N308_03467| N309_10693| N310_02977| N311_10975| N312_01023| N320_01590| N321_11172| N322_05412| N324_08742| N325_02213| N326_06067| N329_08028| N330_01819| N331_12249| N333_08216| N335_08399| N336_12711| N339_02228| N340_14613| N341_05683| PAL_GLEAN10021653| PANDA_001907| regulatory factor 2| TREES_T100012417| UY3_01984| Y1Q_015637| Y956_01131| Z169_11196| irf2

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