The Function of IRF2
Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
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Protein names
Recommended name:
Interferon regulatory factor 2Short name:
IRF-2Top Gene-Substance Interactions
Substances That Increase IRF2
| Substances | Interaction | Organism | Category |
Substances That Decrease IRF2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
Gene Pathways:
Induction:
By viruses and IFN.
Molecular Function:
- Dna Binding
- Rna Polymerase Ii Regulatory Region Sequence-Specific Dna Binding
- Transcriptional Activator Activity, Rna Polymerase Ii Transcription Regulatory Region Sequence-Specific Binding
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- Blood Coagulation
- Cell Proliferation
- Interferon-Gamma-Mediated Signaling Pathway
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Regulation Of Transcription, Dna-Templated
- Type I Interferon Signaling Pathway