The Function of IQGAP2
Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.
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Protein names
Recommended name:
Ras GTPase-activating-like protein IQGAP2- RS457717 (IQGAP2) ??
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Top Gene-Substance Interactions
Substances That Increase IQGAP2
| Substances | Interaction | Organism | Category |
Substances That Decrease IQGAP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 2 expression is enhanced in testis.
Gene Pathways:
Molecular Function:
- Actin Binding
- Gtpase Inhibitor Activity
- Calmodulin Binding
- Phosphatidylinositol-3,4,5-Trisphosphate Binding
- Rho Gtpase Binding
- Rac Gtpase Binding
- Actin Filament Binding
- Arp2/3 Complex Binding
Biological Processes:
- Signal Transduction
- Arp2/3 Complex-Mediated Actin Nucleation
- Thrombin-Activated Receptor Signaling Pathway