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  3. IQGAP2

IQGAP2 (IQ motif containing GTPase activating protein 2)

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The Function of IQGAP2

Binds to activated CDC42 and RAC1 but does not seem to stimulate their GTPase activity. Associates with calmodulin.

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Protein names

Recommended name:

Ras GTPase-activating-like protein IQGAP2

IQGAP2 SNPs

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  1. RS457717 (IQGAP2) ??

Top Gene-Substance Interactions

Substances That Increase IQGAP2

Substances Interaction Organism Category

Substances That Decrease IQGAP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Max
  • Arnt
  • c-Myc
  • GCNF

Tissue specificity:

Isoform 2 expression is enhanced in testis.

Gene Pathways:

  • Regulation of actin cytoskeleton

Molecular Function:

  • Actin Binding
  • Actin Filament Binding
  • Arp2/3 Complex Binding
  • Calmodulin Binding
  • Gtpase Inhibitor Activity
  • Phosphatidylinositol-3,4,5-Trisphosphate Binding
  • Rac Gtpase Binding
  • Rho Gtpase Binding

Biological Processes:

  • Arp2/3 Complex-Mediated Actin Nucleation
  • Signal Transduction
  • Thrombin-Activated Receptor Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| IQ motif containing GTPase activating protein 1| A630053O10| AS27_09930| AS28_06223| CB1_000917005| D623_10035951| fc20f09| H920_03170| IQGAP1| M91_07735| M959_03612| N300_04339| N301_04117| N303_00958| N305_02348| N306_10910| N307_04957| N308_15584| N311_07487| N320_04025| N322_04280| N324_10892| N326_10180| N328_02185| N330_14133| N331_05508| N332_08892| N335_06631| N336_07976| N339_10550| N340_01779| N341_05714| PAL_GLEAN10024903| PANDA_015437| proteinase-activated receptor 1| Ras GTPase-activating-like IQGAP2| Ras GTPase-activating-like protein| ras GTPase-activating-like protein IQGAP1| ras GTPase-activating-like protein IQGAP2| Ras GTPase-activating-like protein IQGAP2-like protein| XIQGAP2| Y1Q_024431| Y956_06891| Z169_10270| iqgap2

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