The Function of IPO5
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Protein names
Recommended name:
Importin-5Alternative name(s):
Imp5Importin subunit beta-3
Karyopherin beta-3
Ran-binding protein 5
RanBP5
- RS16954776 (IPO5) ??
- RS9517132 (IPO5) ??
- RS9584669 (IPO5) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
---|
Technical
The following transcription factors affect gene expression:
Molecular Function:
- Gtpase Inhibitor Activity
- Nuclear Localization Sequence Binding
- Poly(A) Rna Binding
- Protein Transporter Activity
- Ran Gtpase Binding
Biological Processes:
- Cellular Response To Amino Acid Stimulus
- Nls-Bearing Protein Import Into Nucleus
- Positive Regulation Of Protein Import Into Nucleus
- Protein Import Into Nucleus, Docking
- Protein Import Into Nucleus, Translocation
- Ribosomal Protein Import Into Nucleus
- Viral Process