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  3. IPO5

IPO5 (Importin 5)

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The Function of IPO5

Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.

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Protein names

Recommended name:

Importin-5

Alternative name(s):

Imp5
Importin subunit beta-3
Karyopherin beta-3
Ran-binding protein 5
RanBP5

IPO5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS16954776 (IPO5) ??
  2. RS9517132 (IPO5) ??
  3. RS9584669 (IPO5) ??

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • STAT5A
  • ARP-1
  • c-Rel
  • Nkx3-1 v1
  • Nkx3-1
  • RelA

Molecular Function:

  • Gtpase Inhibitor Activity
  • Nuclear Localization Sequence Binding
  • Poly(A) Rna Binding
  • Protein Transporter Activity
  • Ran Gtpase Binding

Biological Processes:

  • Cellular Response To Amino Acid Stimulus
  • Nls-Bearing Protein Import Into Nucleus
  • Positive Regulation Of Protein Import Into Nucleus
  • Protein Import Into Nucleus, Docking
  • Protein Import Into Nucleus, Translocation
  • Ribosomal Protein Import Into Nucleus
  • Viral Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_03447| AS27_01237| AS28_11329| C76941| CB1_060782102| D623_10014780| H920_15162| I79_000383| imb3| imp5| importin-5| importin-5-like protein| importin beta 3| importin beta-3| importin beta-3 subunit| importin subunit beta-3| ipo5-a| ipo5-b| kap beta 3| karyopherin-B3| karyopherin beta-3| karyopherin (importin) beta 3| Kpnb3| M91_18745| M959_06834| MDA_GLEAN10014494| N300_05784| N301_00910| N302_02079| N303_02877| N305_09256| N306_07114| N307_10550| N309_05661| N310_05682| N311_02304| N312_12185| N320_13007| N321_14213| N325_03964| N326_08527| N327_00815| N328_02833| N330_01060| N331_01678| N332_14372| N333_07812| N335_05061| N336_06136| N339_02793| N340_09410| N341_01034| PANDA_002848| Pse1| ran-binding protein 5| RAN binding protein 5| RAN-binding protein 5-like| ranbp5| ranbp6| Ran_GTP binding protein 5| Ran GTP binding protein 5-like protein| TREES_T100006211| UY3_13117| Y1Q_022802| Y956_11678| Z169_05696| ipo5

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