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  3. INSIG1

INSIG1 (Insulin induced gene 1)

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The Function of INSIG1

Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.

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Protein names

Recommended name:

Insulin-induced gene 1 protein

Short name:

INSIG-1

Top Gene-Substance Interactions

INSIG1 Interacts with These Diseases

Disease Score

Substances That Increase INSIG1

Substances Interaction Organism Category

Substances That Decrease INSIG1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • PPAR-gamma2

Tissue specificity:

Expressed in all tissues tested with highest expression in the liver.

Gene Pathways:

  • Metabolism

Induction:

By insulin.

Biological Processes:

  • Cell Proliferation
  • Cholesterol Biosynthetic Process
  • Cranial Suture Morphogenesis
  • Inner Ear Morphogenesis
  • Metabolic Process
  • Middle Ear Morphogenesis
  • Negative Regulation Of Cargo Loading Into Copii-Coated Vesicle
  • Negative Regulation Of Fat Cell Differentiation
  • Negative Regulation Of Fatty Acid Biosynthetic Process
  • Negative Regulation Of Steroid Biosynthetic Process
  • Palate Development
  • Srebp Signaling Pathway
  • Triglyceride Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14936| Anapl_10819| AS27_08317| AS28_01741| CB1_000880037| cl6| CL-6| D623_10012145| fb55a03| fi35b10| growth response protein (CL-6)| immediate-early protein CL-6| INSIG-1| INSIG-1 membrane protein| Insulin-induced 1| Insulin-induced 1 protein| insulin-induced gene 1 protein| insulin-induced growth response protein CL-6| insulin induced protein 1| Insulin-induced protein 1 protein| insulin-induced protein INSIG1| M91_18030| M959_03725| MDA_GLEAN10006064| N300_04219| N301_05981| N302_12115| N303_03795| N305_11370| N306_13112| N307_09125| N308_13006| PAL_GLEAN10003667| PANDA_015700| TREES_T100017646| UY3_05337| Y1Q_021192| Y956_14104| Z169_01086| insig1

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