The Function of INSIG1
Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.
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Protein names
Recommended name:
Insulin-induced gene 1 proteinShort name:
INSIG-1Top Gene-Substance Interactions
INSIG1 Interacts with These Diseases
| Disease | Score |
Substances That Increase INSIG1
| Substances | Interaction | Organism | Category |
Substances That Decrease INSIG1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues tested with highest expression in the liver.
Gene Pathways:
Induction:
By insulin.
Biological Processes:
- Cell Proliferation
- Cholesterol Biosynthetic Process
- Cranial Suture Morphogenesis
- Inner Ear Morphogenesis
- Metabolic Process
- Middle Ear Morphogenesis
- Negative Regulation Of Cargo Loading Into Copii-Coated Vesicle
- Negative Regulation Of Fat Cell Differentiation
- Negative Regulation Of Fatty Acid Biosynthetic Process
- Negative Regulation Of Steroid Biosynthetic Process
- Palate Development
- Srebp Signaling Pathway
- Triglyceride Metabolic Process