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  3. INMT

INMT (Indolethylamine N-methyltransferase)

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The Function of INMT

Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds.

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Protein names

Recommended name:

Indolethylamine N-methyltransferase

Short name:

TEMT

Alternative name(s):

Indolamine N-methyltransferase
Aromatic alkylamine N-methyltransferase
Amine N-methyltransferase
Arylamine N-methyltransferase
Thioether S-methyltransferase

Top Gene-Substance Interactions

Substances That Increase INMT

Substances Interaction Organism Category

Substances That Decrease INMT

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • FOXO3
  • FOXO3a
  • FOXI1
  • Cdc5
  • AREB6
  • FOXO3b

Tissue specificity:

Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain.

Gene Pathways:

  • Tryptophan metabolism
  • Selenocompound metabolism

Molecular Function:

  • Amine N-Methyltransferase Activity
  • Thioether S-Methyltransferase Activity

Biological Processes:

  • Amine Metabolic Process
  • Methylation
  • Response To Toxic Substance
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| amine N-methyltransferase| aromatic alkylamine N-methyltransferase| arylamine N-methyltransferase| CB1_001026023| GW7_07094| indolamine N-methyltransferase| indolethylamine N-methyltransferase-like protein| M91_19652| nicotine N-methyltransferase| nnmt| TEMT| thioether S-methyltransferase| TREES_T100002717| inmt

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