The Function of INHBC
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
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Protein names
Recommended name:
Inhibin beta C chainAlternative name(s):
Activin beta-C chain- RS3741414 (INHBC) ??
- RS61352607 (INHBC) ??
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Top Gene-Substance Interactions
Substances That Increase INHBC
| Substances | Interaction | Organism | Category |
Substances That Decrease INHBC
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in benign prostatic hyperplasia.
Gene Pathways:
Molecular Function:
Biological Processes:
- Positive Regulation Of Pathway-Restricted Smad Protein Phosphorylation
- Regulation Of Apoptotic Process
- Regulation Of Mapk Cascade
- Cell Development
- Smad Protein Signal Transduction