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  3. ING1

ING1 (Inhibitor of growth family member 1)

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The Function of ING1

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

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Protein names

Recommended name:

Inhibitor of growth protein 1

Top Gene-Substance Interactions

ING1 Interacts with These Diseases

Disease Score

Substances That Increase ING1

Substances Interaction Organism Category

Substances That Decrease ING1

Substances Interaction Organism Category

Advanced Summary

     From NCBI Gene: Squamous cell carcinoma of the head and neckFrom UniProt: Squamous cell carcinoma of the head and neck (HNSCC): A non-melanoma skin cancer affecting the head and neck. The hallmark of cutaneous SCC is malignant transformation of normal epidermal keratinocytes. [MIM:275355]

     From NCBI Gene: This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] From UniProt: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • p53

Tissue specificity:

Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.

Molecular Function:

  • Methylated Histone Binding
  • Zinc Ion Binding

Biological Processes:

  • Cell Cycle
  • Chromatin Organization
  • Negative Regulation Of Cell Growth
  • Negative Regulation Of Cell Proliferation
  • Regulation Of Cell Death
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| p47| p33| A306_10313| AS27_15791| AS28_10461| CB1_001951005| growth inhibitor ING1| growth inhibitory protein ING1| H920_03567| inhibitor of growth family, member 1| Inhibitor of growth protein 1| inhibitor of growth protein 1-like protein| inhibitor of growth protein 2| M91_05794| M959_01927| mING1h| N300_06751| N301_05287| N302_15313| N303_11727| N305_11636| N306_03153| N307_07218| N308_11643| N309_02410| N310_05962| N311_10591| N312_12912| N320_00272| N321_06581| N322_00273| N324_06302| N325_03841| N326_10309| N327_07096| N329_07609| N330_08709| N332_01290| N333_13687| N334_11396| N335_14419| N336_11819| N340_08001| N341_08612| p24ING1c| p33ing1| p33ing1b| p33ING1c| p37Ing1b| p47ing1a| PAL_GLEAN10013713| PANDA_014038| TREES_T100021082| tumor suppressor ING1| UY3_10865| xing1| Y1Q_006563| Y956_11964| ing1

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