The Function of IMPDH2
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
Protein names
Recommended name:
Inosine-5'-monophosphate dehydrogenase 2Short name:
IMPD 2Alternative name(s):
IMP dehydrogenase 2IMPDH 2
IMPDH-II
- RS11706052 (IMPDH2) ??
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Top Gene-Substance Interactions
Substances That Increase IMPDH2
| Substances | Interaction | Organism | Category |
Substances That Decrease IMPDH2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Induction:
Selectively up-regulated in neoplastic and replicating cells.
Enzyme Regulation:
Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. Subject to product inhibition by XMP and NADH. Also inhibited by ADP.
Molecular Function:
Biological Processes:
- Cellular Response To Interleukin-4
- Gmp Biosynthetic Process
- Gtp Biosynthetic Process
- Lymphocyte Proliferation
- Protein Homotetramerization
- Purine Ribonucleoside Monophosphate Biosynthetic Process
- Retina Development In Camera-Type Eye
Drug Bank:
- Mercaptopurine
- Mycophenolic Acid
- Mycophenolate Mofetil