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  3. IMPAD1

IMPAD1 (Inositol monophosphatase domain containing 1)

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The Function of IMPAD1

May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.

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Protein names

Recommended name:

Inositol monophosphatase 3

Short name:

IMP 3

Alternative name(s):

IMPase 3
Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
Golgi-resident PAP phosphatase
gPAPP
Inositol monophosphatase domain-containing protein 1
Inositol-1(or 4
Myo-inositol monophosphatase A3

Top Gene-Substance Interactions

Substances That Increase IMPAD1

Substances Interaction Organism Category

Substances That Decrease IMPAD1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Evi-1
  • RORalpha1
  • RORalpha2
  • Nkx2-5
  • GATA-2
  • Pax-5
  • E47
  • Hand1
  • Ik-1

Enzyme Regulation:

Strongly inhibited by lithium.

Molecular Function:

  • 3'(2'),5'-Bisphosphate Nucleotidase Activity
  • 3'-Nucleotidase Activity
  • Inositol Monophosphate 1-Phosphatase Activity
  • Inositol Monophosphate 3-Phosphatase Activity
  • Inositol Monophosphate 4-Phosphatase Activity
  • Magnesium Ion Binding

Biological Processes:

  • Chondrocyte Development
  • Chondroitin Sulfate Metabolic Process
  • Embryonic Digit Morphogenesis
  • Endochondral Ossification
  • Inositol Biosynthetic Process
  • Phosphatidylinositol Phosphorylation
  • Post-Embryonic Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| Ac2-190| AL022796| AS27_01755| AS28_15138| B230207P20| CB1_000844008| D623_10024659| EH28_12717| Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase| golgi-resident nucleotide phosphatase| Golgi-resident PAP phosphatase| gPAPP| GW7_13080| H920_18137| I79_008439| IMP 3| IMP-3| IMPA3| IMPase 3| inositol-1(or 4)-monophosphatase 3| Inositol monophosphatase 3| inositol monophosphatase 3-like protein| Inositol monophosphatase domain-containing protein 1| Jaws| M91_19581| MDA_GLEAN10024569| myo-inositol monophosphatase A3| N300_08400| N301_15358| N302_13378| N303_03918| N305_09217| N306_12423| N307_01919| N308_01217| N309_04755| N310_11696| N311_07028| N312_11877| N320_00831| N321_14315| N322_11648| N324_07246| N325_06579| N326_11432| N328_10642| N329_13228| N330_03710| N331_02441| N332_07410| N333_10497| N334_10761| N335_08459| N336_00526| N339_09094| PAL_GLEAN10019266| PANDA_006833| RGD1306455| TREES_T100010510| UY3_02006| Y1Q_008279| Y956_15580| Z169_08359| impad1

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