The Function of IMPAD1
May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation.
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Protein names
Recommended name:
Inositol monophosphatase 3Short name:
IMP 3Alternative name(s):
IMPase 3Golgi 3-prime phosphoadenosine 5-prime phosphate 3-prime phosphatase
Golgi-resident PAP phosphatase
gPAPP
Inositol monophosphatase domain-containing protein 1
Inositol-1(or 4
Myo-inositol monophosphatase A3
Top Gene-Substance Interactions
Substances That Increase IMPAD1
| Substances | Interaction | Organism | Category |
Substances That Decrease IMPAD1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Enzyme Regulation:
Strongly inhibited by lithium.
Molecular Function:
- 3'(2'),5'-Bisphosphate Nucleotidase Activity
- 3'-Nucleotidase Activity
- Inositol Monophosphate 1-Phosphatase Activity
- Inositol Monophosphate 3-Phosphatase Activity
- Inositol Monophosphate 4-Phosphatase Activity
- Magnesium Ion Binding
Biological Processes:
- Chondrocyte Development
- Chondroitin Sulfate Metabolic Process
- Embryonic Digit Morphogenesis
- Endochondral Ossification
- Inositol Biosynthetic Process
- Phosphatidylinositol Phosphorylation
- Post-Embryonic Development