The Function of IMPA1
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates.
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Protein names
Recommended name:
Inositol monophosphatase 1Short name:
IMP 1Alternative name(s):
IMPase 1D-galactose 1-phosphate phosphatase
Inositol-1(or 4
Lithium-sensitive myo-inositol monophosphatase A1
Top Gene-Substance Interactions
IMPA1 Interacts with These Diseases
| Disease | Score |
Substances That Increase IMPA1
| Substances | Interaction | Organism | Category |
Substances That Decrease IMPA1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Enzyme Regulation:
Activity with myo-inositol monophosphate and D-galactose 1-phosphate is inhibited by Li(+), Ca(2+) and Mn(2+), but also by Mg(2+) at concentrations above 3 mM.
Molecular Function:
- Magnesium Ion Binding
- Inositol Monophosphate 1-Phosphatase Activity
- Manganese Ion Binding
- Lithium Ion Binding
- Identical Protein Binding
- Protein Homodimerization Activity
- Inositol Monophosphate 3-Phosphatase Activity
- Inositol Monophosphate 4-Phosphatase Activity
- Inositol Monophosphate Phosphatase Activity
Biological Processes:
- Inositol Metabolic Process
- Inositol Biosynthetic Process
- Phosphatidylinositol Biosynthetic Process
- Phosphate-Containing Compound Metabolic Process
- Signal Transduction
- Inositol Phosphate Metabolic Process
- Phosphatidylinositol Phosphorylation
- Inositol Phosphate Dephosphorylation