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  3. IMMP2L

IMMP2L (Inner mitochondrial membrane peptidase subunit 2)

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Summary of IMMP2L

The gene codes for protein, inner mitochondrial membrane peptidase subunit 2. It is important for catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex [R].

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The Function of IMMP2L

Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

Protein names

Recommended name:

Mitochondrial inner membrane protease subunit 2

Alternative name(s):

IMP2-like protein

IMMP2L SNPs

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  1. RS10279573 (IMMP2L) ??
  2. RS12531640 (IMMP2L) ??
  3. RS13240464 (IMMP2L) ??
  4. RS17157913 (IMMP2L) ??
  5. RS73201076 (IMMP2L) ??

Top Gene-Substance Interactions

Substances That Increase IMMP2L

Substances Interaction Organism Category

Substances That Decrease IMMP2L

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Gilles de la Tourette syndrome (GTS): Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. [MIM:137580]

     From NCBI Gene: This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011] From UniProt: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • FOXO4
  • Nkx2-2
  • Egr-2
  • HSF2
  • HFH-1
  • NCX/Ncx

Tissue specificity:

Expressed in all tissues tested except adult liver and lung.

Gene Pathways:

  • Protein export

Molecular Function:

  • Peptidase Activity
  • Serine-Type Endopeptidase Activity

Biological Processes:

  • Blood Circulation
  • Brain Development
  • Cellular Response To Dna Damage Stimulus
  • Cerebellum Vasculature Development
  • Mitochondrial Respiratory Chain Complex Assembly
  • Ovarian Follicle Development
  • Ovulation
  • Protein Processing Involved In Protein Targeting To Mitochondrion
  • Respiratory Electron Transport Chain
  • Signal Peptide Processing
  • Spermatogenesis
  • Superoxide Metabolic Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| H920_13507| IMMP2L-IT1| imp2| IMP2 inner mitochondrial membrane peptidase-like| IMP2 inner mitochondrial membrane peptidase-like protein| IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)| IMP2-LIKE| IMP2-like protein| inner mitochondrial membrane peptidase 2 like| M91_01928| M959_00823| mitochondrial inner membrane protease subunit 2| mitochondrial inner membrane protease subunit 2-like| N300_02062| N301_12095| N302_08756| N303_01012| N305_05002| N329_05225| UY3_17705| Y1Q_007366| Y956_02893| immp2l

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