Summary of IMMP2L
The gene codes for protein, inner mitochondrial membrane peptidase subunit 2. It is important for catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex [R].
The Function of IMMP2L
Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Protein names
Recommended name:
Mitochondrial inner membrane protease subunit 2Alternative name(s):
IMP2-like protein- RS10279573 (IMMP2L) ??
- RS12531640 (IMMP2L) ??
- RS13240464 (IMMP2L) ??
- RS17157913 (IMMP2L) ??
- RS73201076 (IMMP2L) ??
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Top Gene-Substance Interactions
Substances That Increase IMMP2L
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Substances That Decrease IMMP2L
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Advanced Summary
From UniProt: Gilles de la Tourette syndrome (GTS): Neurologic disorder manifested particularly by motor and vocal tics and associated with behavioral abnormalities. [MIM:137580]
From NCBI Gene: This gene encodes a protein involved in processing the signal peptide sequences used to direct mitochondrial proteins to the mitochondria. The encoded protein resides in the mitochondria and is one of the necessary proteins for the catalytic activity of the mitochondrial inner membrane peptidase (IMP) complex. Two variants that encode the same protein have been described for this gene. [provided by RefSeq, Sep 2011] From UniProt: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.
Conditions with Increased Gene Activity
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in all tissues tested except adult liver and lung.
Gene Pathways:
Molecular Function:
Biological Processes:
- Blood Circulation
- Brain Development
- Cellular Response To Dna Damage Stimulus
- Cerebellum Vasculature Development
- Mitochondrial Respiratory Chain Complex Assembly
- Ovarian Follicle Development
- Ovulation
- Protein Processing Involved In Protein Targeting To Mitochondrion
- Respiratory Electron Transport Chain
- Signal Peptide Processing
- Spermatogenesis
- Superoxide Metabolic Process