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  3. IL5

IL5 (Interleukin 5)

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Summary of IL5

IL-5 is an anti-inflammatory cytokine that is part of the Th2 arm of the immune system.  It's released by T Helper 2 cells. 

0 users want this gene increased, 0 users want it decreased

The Function of IL5

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.

Protein names

Recommended name:

Interleukin-5

Short name:

TRF

Alternative name(s):

IL-5
B-cell differentiation factor I
Eosinophil differentiation factor
T-cell replacing factor

IL5 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2069812 (IL5) ??
  2. RS4143832 (IL5) ??
  3. RS4705952 (IL5) ??

Top Gene-Substance Interactions

IL5 Interacts with These Diseases

Disease Score

Substances That Increase IL5

Substances Interaction Organism Category

Substances That Decrease IL5

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • NF-kappaB1
  • C/EBPalpha
  • GATA-1
  • GATA-3
  • p300

Gene Pathways:

  • Immune System
  • Autoimmune thyroid disease
  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • T cell receptor signaling pathway
  • Allograft rejection
  • Asthma
  • Hematopoietic cell lineage
  • Intestinal immune network for IgA production
  • Fc epsilon RI signaling pathway

Molecular Function:

  • Cytokine Activity
  • Interleukin-5 Receptor Binding
  • Protein Tyrosine Kinase Activity
  • Ras Guanyl-Nucleotide Exchange Factor Activity

Biological Processes:

  • Cytokine-Mediated Signaling Pathway
  • Immune Response
  • Inflammatory Response
  • Mapk Cascade
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Eosinophil Differentiation
  • Positive Regulation Of Immunoglobulin Secretion
  • Positive Regulation Of Jak-Stat Cascade
  • Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
  • Positive Regulation Of Podosome Assembly
  • Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Positive Regulation Of Transcription, Dna-Templated

Drug Bank:

  • Mepolizumab
  • Pranlukast
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| B-cell differentiation factor I| B-cell growth factor II| BCGF-II| colony-stimulating factor, eosinophil| cytotoxic T-lymphocyte inducer| D623_10032557| EDF| eosinophil differentiation factor| H920_12010| IL-5| Interleukin-5| interleukin 5 (colony-stimulating factor, eosinophil)| MDA_GLEAN10009173| PAL_GLEAN10016895| PANDA_000727| T-cell replacing factor| TRF| il5

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