Summary of IL5
The IL5 gene encodes interleukin 5 (IL-5), an inflammatory cytokine. It is part of the Th2 immune response [R].
IL-5 stimulates the growth and differentiation of B cells and eosinophils, two types of specialized white blood cell. As such, IL-5 may be involved in inflammatory diseases caused by excess eosinophil activity [R].
Variants in IL5 have been associated with [R, R, R, R, R, R]:
- Coronary artery disease
- Fibromyalgia
- Eosinophilic granulomatosis with polyangiitis (EGPA)
- Eosinophilic esophagitis
- Asthma
0 users want this gene increased,
0 users want it decreased
Protein names
Recommended name:
Interleukin-5Short name:
TRFAlternative name(s):
IL-5B-cell differentiation factor I
Eosinophil differentiation factor
T-cell replacing factor
- RS2069812 (IL5) ??
- RS4143832 (IL5) ??
- RS4705952 (IL5) ??
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Top Gene-Substance Interactions
IL5 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL5
| Substances | Interaction | Organism | Category |
Substances That Decrease IL5
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Protein Tyrosine Kinase Activity
- Ras Guanyl-Nucleotide Exchange Factor Activity
- Cytokine Activity
- Interleukin-5 Receptor Binding
Biological Processes:
- Mapk Cascade
- Inflammatory Response
- Immune Response
- Cytokine-Mediated Signaling Pathway
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Eosinophil Differentiation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Jak-Stat Cascade
- Positive Regulation Of Peptidyl-Tyrosine Phosphorylation
- Positive Regulation Of Immunoglobulin Secretion
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of Podosome Assembly
Drug Bank:
- Mepolizumab
- Pranlukast