Summary of IL4R
The Function of IL4R
Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Protein names
Recommended name:
Interleukin-4 receptor subunit alphaShort name:
IL-4RAAlternative name(s):
IL-4 receptor subunit alphaIL-4R subunit alpha
IL-4R-alpha
CD antigen CD124
Soluble IL-4 receptor subunit alpha
Soluble IL-4R-alpha
sIL4Ralpha/prot
IL-4-binding protein
IL4-BP
- RS1801275 (IL4R) ??
- RS1805011 (IL4R) ??
- RS1805012 (IL4R) ??
- RS1805013 (IL4R) ??
- RS1805015 (IL4R) ??
- RS1805016 (IL4R) ??
- RS1859308 (IL4R) ??
- RS2107357 (IL4R) ??
- RS3024585 (IL4R) ??
- RS3024667 (IL4R) ??
- RS3024685 (IL4R) ??
- RS8832 (IL4R) ??
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Top Gene-Substance Interactions
IL4R Interacts with These Diseases
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Substances That Increase IL4R
| Substances | Interaction | Organism | Category |
Substances That Decrease IL4R
| Substances | Interaction | Organism | Category |
Advanced Summary
From NCBI Gene: Human immunodeficiency virus type 1, susceptibility toIge responsiveness, atopic
From NCBI Gene: This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012] From UniProt: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 1 and isoform 2 are highly expressed in activated T-cells.
Gene Pathways:
Molecular Function:
Biological Processes:
- Defense Response To Protozoan
- Immune Response
- Immunoglobulin Mediated Immune Response
- Negative Regulation Of T-Helper 1 Cell Differentiation
- Ovulation
- Positive Regulation Of Chemokine Secretion
- Positive Regulation Of Immunoglobulin Production
- Positive Regulation Of Macrophage Activation
- Positive Regulation Of Mast Cell Degranulation
- Positive Regulation Of Myoblast Fusion
- Positive Regulation Of T-Helper 2 Cell Differentiation
- Production Of Molecular Mediator Involved In Inflammatory Response
- Regulation Of Cell Proliferation
- Response To Estrogen
- Signal Transduction