Summary of IL4
The IL4 gene encodes interleukin-4, an important inflammatory marker [R].
IL-4 is a proinflammatory cytokine. It stimulates the Th2 immune response, meaning that it promotes an antibody response to pathogens. High IL-4 levels may contribute to allergic reactions [R, R, R].
IL-4 also plays a role in DNA synthesis [R].
Variants in IL4 have been linked to [R, R, R]:
- Asthma
- Post-traumatic disorders
- Systemic lupus erythematosus
Protein names
Recommended name:
Interleukin-4Short name:
IL-4Alternative name(s):
B-cell stimulatory factor 1BSF-1
Binetrakin
Lymphocyte stimulatory factor 1
Pitrakinra
- RS2069757 (IL4) ??
- RS2070874 (IL4) ??
- RS2227284 (IL4) ??
- RS2243248 (IL4) ??
- RS2243250 (IL4) ??
- RS2243266 (IL4) ??
- RS2243268 (IL4) ??
- RS2243270 (IL4) ??
- RS2243290 (IL4) ??
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Top Gene-Substance Interactions
IL4 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL4
| Substances | Interaction | Organism | Category |
Substances That Decrease IL4
| Substances | Interaction | Organism | Category |
Advanced Summary
From UniProt: Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. [MIM:601367]
From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13 . STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13 . This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] From UniProt: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Microglial Cell Activation
- Innate Immune Response In Mucosa
- Positive Regulation Of Defense Response To Virus By Host
- T-Helper 1 Cell Lineage Commitment
- Negative Regulation Of Acute Inflammatory Response
- Negative Regulation Of Chronic Inflammatory Response
- Chemotaxis
- Immune Response
- Cellular Defense Response
- Female Pregnancy
- Response To Nutrient
- Cholesterol Metabolic Process
- Regulation Of Proton Transport
- Negative Regulation Of Epithelial Cell Migration
- Response To Organic Cyclic Compound
- B Cell Differentiation
- Positive Regulation Of B Cell Proliferation
- B Cell Costimulation
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-13 Production
- Response To Cytokine
- T-Helper 2 Cell Cytokine Production
- Type 2 Immune Response
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Activated T Cell Proliferation
- Regulation Of Phosphorylation
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Defense Response To Protozoan
- Myeloid Dendritic Cell Differentiation
- Negative Regulation Of Macrophage Activation
- Negative Regulation Of Apoptotic Process
- Positive Regulation Of Mast Cell Degranulation
- Negative Regulation Of Nitric Oxide Biosynthetic Process
- T-Helper 2 Cell Differentiation
- Positive Regulation Of Chemokine Biosynthetic Process
- Connective Tissue Growth Factor Biosynthetic Process
- Regulation Of Isotype Switching
- Positive Regulation Of Mhc Class Ii Biosynthetic Process
- Response To Ethanol
- Positive Regulation Of T Cell Differentiation
- Negative Regulation Of Osteoclast Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Isotype Switching To Ige Isotypes
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Regulation Of Immune Response
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Retina Development In Camera-Type Eye
- Negative Regulation Of White Fat Cell Proliferation
- Cellular Response To Mercury Ion
- Positive Regulation Of Mononuclear Cell Migration
- Dendritic Cell Differentiation
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Positive Regulation Of Myoblast Fusion
- Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
- Negative Regulation Of Complement-Dependent Cytotoxicity
- Negative Regulation Of T-Helper 17 Cell Differentiation
- Negative Regulation Of Endothelial Cell Apoptotic Process
- Positive Regulation Of Eosinophil Chemotaxis
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway