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IL4 (Interleukin 4)

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Summary of IL4

IL4 (interleukin 4) encodes a protein that helps regulate the immune system (R). 

IL4 stimulates the Th2 arm of the immune system.

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The Function of IL4

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.

Protein names

Recommended name:

Interleukin-4

Short name:

IL-4

Alternative name(s):

B-cell stimulatory factor 1
BSF-1
Binetrakin
Lymphocyte stimulatory factor 1
Pitrakinra

IL4 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2069757 (IL4) ??
  2. RS2070874 (IL4) ??
  3. RS2227284 (IL4) ??
  4. RS2243248 (IL4) ??
  5. RS2243250 (IL4) ??
  6. RS2243266 (IL4) ??
  7. RS2243268 (IL4) ??
  8. RS2243270 (IL4) ??
  9. RS2243290 (IL4) ??

Top Gene-Substance Interactions

IL4 Interacts with These Diseases

Disease Score

Substances That Increase IL4

Substances Interaction Organism Category

Substances That Decrease IL4

Substances Interaction Organism Category

Advanced Summary

     From UniProt: Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. [MIM:601367]

     From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13 . STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13 . This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] From UniProt: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GATA-3
  • STAT6
  • NF-AT2
  • NF-kappaB
  • NF-kappaB1
  • AhR
  • IRF-1

Gene Pathways:

  • Asthma
  • T cell receptor signaling pathway
  • Leishmaniasis
  • Allograft rejection
  • Measles
  • Intestinal immune network for IgA production
  • Autoimmune thyroid disease
  • Fc epsilon RI signaling pathway
  • Hematopoietic cell lineage
  • Jak-STAT signaling pathway
  • Cytokine-cytokine receptor interaction

Molecular Function:

  • Cytokine Activity
  • Interleukin-4 Receptor Binding
  • Growth Factor Activity

Biological Processes:

  • Microglial Cell Activation
  • Innate Immune Response In Mucosa
  • Positive Regulation Of Defense Response To Virus By Host
  • T-Helper 1 Cell Lineage Commitment
  • Negative Regulation Of Acute Inflammatory Response
  • Negative Regulation Of Chronic Inflammatory Response
  • Chemotaxis
  • Immune Response
  • Cellular Defense Response
  • Female Pregnancy
  • Response To Nutrient
  • Cholesterol Metabolic Process
  • Regulation Of Proton Transport
  • Negative Regulation Of Epithelial Cell Migration
  • Response To Organic Cyclic Compound
  • B Cell Differentiation
  • Positive Regulation Of B Cell Proliferation
  • B Cell Costimulation
  • Positive Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-13 Production
  • Response To Cytokine
  • T-Helper 2 Cell Cytokine Production
  • Type 2 Immune Response
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of Activated T Cell Proliferation
  • Regulation Of Phosphorylation
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
  • Defense Response To Protozoan
  • Myeloid Dendritic Cell Differentiation
  • Negative Regulation Of Macrophage Activation
  • Negative Regulation Of Apoptotic Process
  • Positive Regulation Of Mast Cell Degranulation
  • Negative Regulation Of Nitric Oxide Biosynthetic Process
  • T-Helper 2 Cell Differentiation
  • Positive Regulation Of Chemokine Biosynthetic Process
  • Connective Tissue Growth Factor Biosynthetic Process
  • Regulation Of Isotype Switching
  • Positive Regulation Of Mhc Class Ii Biosynthetic Process
  • Response To Ethanol
  • Positive Regulation Of T Cell Differentiation
  • Negative Regulation Of Osteoclast Differentiation
  • Negative Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription, Dna-Templated
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Isotype Switching To Ige Isotypes
  • Positive Regulation Of Isotype Switching To Igg Isotypes
  • Regulation Of Immune Response
  • Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Retina Development In Camera-Type Eye
  • Negative Regulation Of White Fat Cell Proliferation
  • Cellular Response To Mercury Ion
  • Positive Regulation Of Mononuclear Cell Migration
  • Dendritic Cell Differentiation
  • Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
  • Positive Regulation Of Myoblast Fusion
  • Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
  • Negative Regulation Of Complement-Dependent Cytotoxicity
  • Negative Regulation Of T-Helper 17 Cell Differentiation
  • Negative Regulation Of Endothelial Cell Apoptotic Process
  • Positive Regulation Of Eosinophil Chemotaxis
  • Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| AS28_08218| B cell growth factor 1| B-cell growth factor 1| B-cell IGG differentiation factor| B_cell stimulatory factor 1| B-cell stimulatory factor 1| bcgf1| bcgf-1| binetrakin| BSF1| BSF-1| CB1_000434004| EGK_16838| GW7_12244| IGG1 induction factor| IL2| Il-4| il4/13b| IL-4 delta 3| Il4e12| interleukin-4| interleukin 4/13B| interleukin 4 protein| interleukin 4 variant 2| interleukin 4 variant IL-4delta3| interleukin 4 variant IL-4int2A| interleukin 4 variant IL-4int3A| interleukin 4 variant IL-4int3B| Lymphocyte stimulatory factor 1| MDA_GLEAN10009170| N305_08708| N325_03165| N327_07343| N339_01496| PAL_GLEAN10016891| PANDA_000730| peroxisomal membrane protein PMP34| pitrakinra| Z169_00074| il4

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