Summary of IL4
The Function of IL4
Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Protein names
Recommended name:
Interleukin-4Short name:
IL-4Alternative name(s):
B-cell stimulatory factor 1BSF-1
Binetrakin
Lymphocyte stimulatory factor 1
Pitrakinra
- RS2069757 (IL4) ??
- RS2070874 (IL4) ??
- RS2227284 (IL4) ??
- RS2243248 (IL4) ??
- RS2243250 (IL4) ??
- RS2243266 (IL4) ??
- RS2243268 (IL4) ??
- RS2243270 (IL4) ??
- RS2243290 (IL4) ??
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Top Gene-Substance Interactions
IL4 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL4
| Substances | Interaction | Organism | Category |
Substances That Decrease IL4
| Substances | Interaction | Organism | Category |
Advanced Summary
From UniProt: Ischemic stroke (ISCHSTR): A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. [MIM:601367]
From NCBI Gene: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13 . STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13 . This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] From UniProt: Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727). It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- B Cell Costimulation
- B Cell Differentiation
- Cellular Defense Response
- Cellular Response To Mercury Ion
- Chemotaxis
- Cholesterol Metabolic Process
- Connective Tissue Growth Factor Biosynthetic Process
- Defense Response To Protozoan
- Dendritic Cell Differentiation
- Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
- Female Pregnancy
- Immune Response
- Innate Immune Response In Mucosa
- Microglial Cell Activation
- Myeloid Dendritic Cell Differentiation
- Negative Regulation Of Acute Inflammatory Response
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Chronic Inflammatory Response
- Negative Regulation Of Complement-Dependent Cytotoxicity
- Negative Regulation Of Endothelial Cell Apoptotic Process
- Negative Regulation Of Epithelial Cell Migration
- Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
- Negative Regulation Of Macrophage Activation
- Negative Regulation Of Nitric Oxide Biosynthetic Process
- Negative Regulation Of Osteoclast Differentiation
- Negative Regulation Of T-Helper 17 Cell Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of White Fat Cell Proliferation
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of B Cell Proliferation
- Positive Regulation Of Chemokine Biosynthetic Process
- Positive Regulation Of Defense Response To Virus By Host
- Positive Regulation Of Eosinophil Chemotaxis
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-13 Production
- Positive Regulation Of Isotype Switching To Ige Isotypes
- Positive Regulation Of Isotype Switching To Igg Isotypes
- Positive Regulation Of Mast Cell Degranulation
- Positive Regulation Of Mhc Class Ii Biosynthetic Process
- Positive Regulation Of Mononuclear Cell Migration
- Positive Regulation Of Myoblast Fusion
- Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
- Positive Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Positive Regulation Of T Cell Differentiation
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Regulation Of Immune Response
- Regulation Of Isotype Switching
- Regulation Of Phosphorylation
- Regulation Of Proton Transport
- Response To Cytokine
- Response To Ethanol
- Response To Nutrient
- Response To Organic Cyclic Compound
- Retina Development In Camera-Type Eye
- T-Helper 1 Cell Lineage Commitment
- T-Helper 2 Cell Cytokine Production
- T-Helper 2 Cell Differentiation
- Type 2 Immune Response