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  3. IL33

IL33 (Interleukin 33)

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Summary of IL33

The gene codes for a protein, interleukin 33. It is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells [R].

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The Function of IL33

In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).

Protein names

Recommended name:

Interleukin-33

Short name:

IL-33

Alternative name(s):

Interleukin-1 family member 11
IL-1F11
Nuclear factor from high endothelial venules
NF-HEV
95-270
99-270
109-270

IL33 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS10975488 (IL33) ??
  2. RS10975519 (IL33) ??
  3. RS1342326 (IL33) ??
  4. RS144829310 (IL33) ??
  5. RS16924159 (IL33) ??
  6. RS2381416 (IL33) ??
  7. RS343496 (IL33) ??
  8. RS3939286 (IL33) ??
  9. RS4742170 (IL33) ??
  10. RS7032572 (IL33) ??
  11. RS72699186 (IL33) ??
  12. RS76962799 (IL33) ??
  13. RS928413 (IL33) ??

Top Gene-Substance Interactions

IL33 Interacts with These Diseases

Disease Score

Substances That Increase IL33

Substances Interaction Organism Category

Substances That Decrease IL33

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • C/EBPbeta
  • C/EBPalpha
  • FOXI1
  • IRF-1
  • IRF-2
  • Cdc5
  • HFH-1

Tissue specificity:

Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.

Gene Pathways:

  • Cytosolic DNA-sensing pathway

Molecular Function:

  • Cytokine Activity

Biological Processes:

  • Defense Response To Virus
  • Extrinsic Apoptotic Signaling Pathway
  • Microglial Cell Activation Involved In Immune Response
  • Microglial Cell Proliferation
  • Negative Regulation Of Immunoglobulin Secretion
  • Negative Regulation Of Interferon-Gamma Production
  • Negative Regulation Of Leukocyte Migration
  • Negative Regulation Of T-Helper 1 Type Immune Response
  • Positive Regulation Of Chemokine Secretion
  • Positive Regulation Of Immunoglobulin Secretion
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interleukin-13 Production
  • Positive Regulation Of Interleukin-4 Production
  • Positive Regulation Of Interleukin-5 Production
  • Positive Regulation Of Interleukin-6 Production
  • Positive Regulation Of Macrophage Activation
  • Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Type 2 Immune Response
  • Transcription, Dna-Templated
  • Type 2 Immune Response
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| C9orf26| CB1_001333004| DVS27| DVS27-related protein| H920_03883| I79_018492| IL1F11| IL-33| interleukin-1 family member 11| Interleukin-33| M91_21422| NFEHEV| NF-HEV| nuclear factor for high endothelial venules| nuclear factor from high endothelial venules| PANDA_020976| RGD1311155| TREES_T100016820| il33

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