Summary of IL33
The IL33 gene encodes IL-33, an important inflammatory marker [R].
IL-33 promotes the maturation of Th2 cells and activation of some types of white blood cells (mast cells, basophils, eosinophils, and natural killer cells). It is also an alarmin, a type of signalling molecule that alerts the body to tissue damage. Finally, it regulates the expression of some other genes, including TRAF6 [R, R].
Variants in IL33 have been linked to [R, R, R, R]:
- Asthma
- Inflammatory bowel disease
- Osteosarcoma survival rates
- Alzheimer’s disease
Protein names
Recommended name:
Interleukin-33Short name:
IL-33Alternative name(s):
Interleukin-1 family member 11IL-1F11
Nuclear factor from high endothelial venules
NF-HEV
95-270
99-270
109-270
- RS10975488 (IL33) ??
- RS10975519 (IL33) ??
- RS1342326 (IL33) ??
- RS144829310 (IL33) ??
- RS16924159 (IL33) ??
- RS2381416 (IL33) ??
- RS343496 (IL33) ??
- RS3939286 (IL33) ??
- RS4742170 (IL33) ??
- RS7032572 (IL33) ??
- RS7044343 (IL33) ??
- RS72699186 (IL33) ??
- RS76962799 (IL33) ??
- RS928413 (IL33) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
IL33 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL33
| Substances | Interaction | Organism | Category |
Substances That Decrease IL33
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Gene Pathways:
Molecular Function:
Biological Processes:
- Microglial Cell Activation Involved In Immune Response
- Negative Regulation Of Leukocyte Migration
- Negative Regulation Of T-Helper 1 Type Immune Response
- Positive Regulation Of Type 2 Immune Response
- Transcription, Dna-Templated
- Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Negative Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-13 Production
- Positive Regulation Of Interleukin-4 Production
- Positive Regulation Of Interleukin-5 Production
- Positive Regulation Of Interleukin-6 Production
- Type 2 Immune Response
- Positive Regulation Of Macrophage Activation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Immunoglobulin Secretion
- Negative Regulation Of Immunoglobulin Secretion
- Defense Response To Virus
- Microglial Cell Proliferation
- Positive Regulation Of Chemokine Secretion
- Extrinsic Apoptotic Signaling Pathway