Summary of IL33
The Function of IL33
In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
Protein names
Recommended name:
Interleukin-33Short name:
IL-33Alternative name(s):
Interleukin-1 family member 11IL-1F11
Nuclear factor from high endothelial venules
NF-HEV
95-270
99-270
109-270
- RS10975519 (IL33) ??
- RS1342326 (IL33) ??
- RS16924159 (IL33) ??
- RS2381416 (IL33) ??
- RS343496 (IL33) ??
- RS4742170 (IL33) ??
- RS7032572 (IL33) ??
- RS72699186 (IL33) ??
- RS928413 (IL33) ??
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Top Gene-Substance Interactions
IL33 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL33
| Substances | Interaction | Organism | Category |
Substances That Decrease IL33
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed at high level in high endothelial venules found in tonsils, Peyer patches and mesenteric lymph nodes. Almost undetectable in placenta.
Gene Pathways:
Molecular Function:
Biological Processes:
- Defense Response To Virus
- Extrinsic Apoptotic Signaling Pathway
- Microglial Cell Activation Involved In Immune Response
- Microglial Cell Proliferation
- Negative Regulation Of Immunoglobulin Secretion
- Negative Regulation Of Interferon-Gamma Production
- Negative Regulation Of Leukocyte Migration
- Negative Regulation Of T-Helper 1 Type Immune Response
- Positive Regulation Of Chemokine Secretion
- Positive Regulation Of Immunoglobulin Secretion
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Interleukin-13 Production
- Positive Regulation Of Interleukin-4 Production
- Positive Regulation Of Interleukin-5 Production
- Positive Regulation Of Interleukin-6 Production
- Positive Regulation Of Macrophage Activation
- Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Type 2 Immune Response
- Transcription, Dna-Templated
- Type 2 Immune Response