Summary of IL23A
The IL23A gene encodes interleukin-23 subunit alpha, which combines with IL-12B to form interleukin-23 (IL-23) [R].
IL-23 plays an important role in both innate and adaptive immunity. It increases inflammation and protects against infection by activating the Jak-Stat signalling cascade. It also stimulates memory cells, initiating an immune response against pathogens that the body has previously encountered [R, R, R].
Variants in IL23A have been linked to [R, R, R]:
- Crohn’s disease
- Psoriasis
- Psoriatic arthritis
Protein names
Recommended name:
Interleukin-23 subunit alphaShort name:
IL-23-AAlternative name(s):
IL-23 subunit alphaInterleukin-23 subunit p19
IL-23p19
- RS11171806 (IL23A) ??
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Top Gene-Substance Interactions
IL23A Interacts with These Diseases
| Disease | Score |
Fixes
Substances That Increase IL23A
| Substances | Interaction | Organism | Category |
Substances That Decrease IL23A
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Gene Pathways:
Induction:
Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.
Developmental stage:
Expressed by newborns dendritic cells.
Biological Processes:
- Positive Regulation Of T Cell Mediated Cytotoxicity
- Positive Regulation Of Defense Response To Virus By Host
- Positive Regulation Of T-Helper 1 Type Immune Response
- Inflammatory Response
- Positive Regulation Of Activation Of Jak2 Kinase Activity
- Negative Regulation Of Interleukin-10 Production
- Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-17 Production
- Positive Regulation Of Tumor Necrosis Factor Production
- Positive Regulation Of Natural Killer Cell Activation
- Positive Regulation Of Natural Killer Cell Proliferation
- Positive Regulation Of Tissue Remodeling
- T Cell Proliferation
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Nf-Kappab Import Into Nucleus
- Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Positive Regulation Of Memory T Cell Differentiation
- Innate Immune Response
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Tissue Remodeling
- Positive Regulation Of Inflammatory Response
- Defense Response To Gram-Negative Bacterium
- Positive Regulation Of Nk T Cell Activation
- Positive Regulation Of Nk T Cell Proliferation
- Defense Response To Virus
- Positive Regulation Of Neutrophil Chemotaxis
- Positive Regulation Of T-Helper 17 Type Immune Response
- Positive Regulation Of T-Helper 17 Cell Lineage Commitment