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  3. IL23A

IL23A (Interleukin 23 subunit alpha)

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Summary of IL23A

Studies in animal models of multiple sclerosis showed that IL-23 was responsible for the inflammation observed, not IL-12 as previously thought.

Subsequently, IL-23 was shown to facilitate development of inflammation in numerous other models of immune disease where IL-12 had previously been implicated including models of arthritis, intestinal inflammation, and psoriasis.

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The Function of IL23A

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Protein names

Recommended name:

Interleukin-23 subunit alpha

Short name:

IL-23-A

Alternative name(s):

IL-23 subunit alpha
Interleukin-23 subunit p19
IL-23p19

IL23A SNPs

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  1. RS11171806 (IL23A) ??

Top Gene-Substance Interactions

IL23A Interacts with These Diseases

Disease Score

Fixes

Inhibitors of IL-23:

Curcumin (R)

 

Substances That Increase IL23A

Substances Interaction Organism Category

Substances That Decrease IL23A

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • CUTL1
  • STAT3
  • NF-kappaB1
  • STAT5A
  • STAT1
  • STAT1beta
  • STAT1alpha
  • STAT4
  • STAT6

Tissue specificity:

Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • Tuberculosis
  • Rheumatoid arthritis

Induction:

Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.

Developmental stage:

Expressed by newborns dendritic cells.

Biological Processes:

  • Defense Response To Gram-Negative Bacterium
  • Defense Response To Virus
  • Inflammatory Response
  • Innate Immune Response
  • Negative Regulation Of Interleukin-10 Production
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of Activation Of Jak2 Kinase Activity
  • Positive Regulation Of Defense Response To Virus By Host
  • Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-12 Production
  • Positive Regulation Of Interleukin-17 Production
  • Positive Regulation Of Memory T Cell Differentiation
  • Positive Regulation Of Natural Killer Cell Activation
  • Positive Regulation Of Natural Killer Cell Proliferation
  • Positive Regulation Of Neutrophil Chemotaxis
  • Positive Regulation Of Nf-Kappab Import Into Nucleus
  • Positive Regulation Of Nk T Cell Activation
  • Positive Regulation Of Nk T Cell Proliferation
  • Positive Regulation Of Osteoclast Differentiation
  • Positive Regulation Of T Cell Mediated Cytotoxicity
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of T-Helper 17 Cell Lineage Commitment
  • Positive Regulation Of T-Helper 17 Type Immune Response
  • Positive Regulation Of T-Helper 1 Type Immune Response
  • Positive Regulation Of Tissue Remodeling
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Tumor Necrosis Factor Production
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
  • Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
  • T Cell Proliferation
  • Tissue Remodeling
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

CB1_000449030| EGK_03801| GW7_15754| IL23| IL-23| IL-23A| IL-23-A| IL-23p19| IL23P19| IL-23 p19 subunit| IL-23 subunit alpha| Interleukin 23, alpha subunit p19| interleukin 23 p19| interleukin 23 p19 subunit| interleukin-23 p19 subunit| Interleukin-23 subunit alpha| interleukin 23 subunit p19| interleukin-23 subunit p19| interleukin-six, G-CSF related factor| JKA3 induced upon T-cell activation| p19| PAL_GLEAN10004823| PANDA_004090| SGRF| Y1Q_007568| il23a

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