Summary of IL23A
Studies in animal models of multiple sclerosis showed that IL-23 was responsible for the inflammation observed, not IL-12 as previously thought.
Subsequently, IL-23 was shown to facilitate development of inflammation in numerous other models of immune disease where IL-12 had previously been implicated including models of arthritis, intestinal inflammation, and psoriasis.
The Function of IL23A
Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Protein names
Recommended name:
Interleukin-23 subunit alphaShort name:
IL-23-AAlternative name(s):
IL-23 subunit alphaInterleukin-23 subunit p19
IL-23p19
- RS11171806 (IL23A) ??
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Top Gene-Substance Interactions
IL23A Interacts with These Diseases
Disease | Score |
Fixes
Substances That Increase IL23A
Substances | Interaction | Organism | Category |
Substances That Decrease IL23A
Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Gene Pathways:
Induction:
Up-regulated by a wide array of pathogens and pathogen-products together with self-signals for danger or injury. Up-regulated in psoriatic dermal tissues, in dendritic cells of multiple sclerosis patients and in tumors.
Developmental stage:
Expressed by newborns dendritic cells.
Biological Processes:
- Defense Response To Gram-Negative Bacterium
- Defense Response To Virus
- Inflammatory Response
- Innate Immune Response
- Negative Regulation Of Interleukin-10 Production
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Activation Of Jak2 Kinase Activity
- Positive Regulation Of Defense Response To Virus By Host
- Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-10 Production
- Positive Regulation Of Interleukin-12 Production
- Positive Regulation Of Interleukin-17 Production
- Positive Regulation Of Memory T Cell Differentiation
- Positive Regulation Of Natural Killer Cell Activation
- Positive Regulation Of Natural Killer Cell Proliferation
- Positive Regulation Of Neutrophil Chemotaxis
- Positive Regulation Of Nf-Kappab Import Into Nucleus
- Positive Regulation Of Nk T Cell Activation
- Positive Regulation Of Nk T Cell Proliferation
- Positive Regulation Of Osteoclast Differentiation
- Positive Regulation Of T Cell Mediated Cytotoxicity
- Positive Regulation Of T Cell Proliferation
- Positive Regulation Of T-Helper 17 Cell Lineage Commitment
- Positive Regulation Of T-Helper 17 Type Immune Response
- Positive Regulation Of T-Helper 1 Type Immune Response
- Positive Regulation Of Tissue Remodeling
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tumor Necrosis Factor Production
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
- Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
- T Cell Proliferation
- Tissue Remodeling