Summary of IL23A

Studies in animal models of multiple sclerosis showed that IL-23 was responsible for the inflammation observed, not IL-12 as previously thought.

Subsequently, IL-23 was shown to facilitate development of inflammation in numerous other models of immune disease where IL-12 had previously been implicated including models of arthritis, intestinal inflammation, and psoriasis.

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The Function of IL23A

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Protein names

Recommended name:

Interleukin-23 subunit alpha

Short name:

IL-23-A

Alternative name(s):

IL-23 subunit alpha
Interleukin-23 subunit p19
IL-23p19

Top Gene-Substance Interactions

IL23A Interacts with These Diseases

Fixes

Substances That Increase IL23A

Substances That Decrease IL23A

Conditions with Increased Gene Activity

Conditions with Decreased Gene Activity

Technical