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  3. IL1R1

IL1R1 (Interleukin 1 receptor type 1)

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Summary of IL1R1

The gene codes for a protein, interleukin 1 receptor type 1. It is a regulator involved in several cytokine-induced immune and inflammatory responses [R].

0 users want this gene increased, 0 users want it decreased

The Function of IL1R1

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.

Protein names

Recommended name:

Interleukin-1 receptor type 1

Alternative name(s):

IL-1R-1
IL-1RT-1
IL-1RT1
CD121 antigen-like family member A
Interleukin-1 receptor alpha
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD antigen CD121a
mIL-1R1
mIL-1RI
sIL-1R1
sIL-1RI

IL1R1 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12712127 (IL1R1) ??
  2. RS13019803 (IL1R1) ??
  3. RS1558643 (IL1R1) ??
  4. RS3917225 (IL1R1) ??
  5. RS3917265 (IL1R1) ??
  6. RS6759556 (IL1R1) ??
  7. RS949963 (IL1R1) ??

Top Gene-Substance Interactions

IL1R1 Interacts with These Diseases

Disease Score

Substances That Increase IL1R1

Substances Interaction Organism Category

Substances That Decrease IL1R1

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • AhR
  • Max
  • c-Jun
  • PPAR-alpha
  • c-Fos

Gene Pathways:

  • Immune System
  • MAPK signaling pathway
  • Cytokine-cytokine receptor interaction
  • Apoptosis
  • Osteoclast differentiation
  • Amoebiasis
  • Hematopoietic cell lineage

Molecular Function:

  • Interleukin-1, Type I, Activating Receptor Activity
  • Interleukin-1 Receptor Activity
  • Platelet-Derived Growth Factor Receptor Binding
  • Signal Transducer Activity
  • Transmembrane Signaling Receptor Activity

Biological Processes:

  • Cell Surface Receptor Signaling Pathway
  • Immune Response
  • Interleukin-1-Mediated Signaling Pathway
  • Positive Regulation Of Interleukin-1-Mediated Signaling Pathway
  • Positive Regulation Of Neutrophil Extravasation
  • Regulation Of Inflammatory Response
  • Response To Interleukin-1
  • Cellular Response To Glucose Stimulus
  • Heat Acclimation
  • Ovulation
  • Response To Epidermal Growth Factor
  • Response To Nitric Oxide
  • Response To Radiation
  • Response To Transforming Growth Factor Beta

Drug Bank:

  • Anakinra
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| cd121a| CD121 antigen-like family member A| CD121b| D2S1473| D623_10006813| EGK_05628| H920_08037| IL1R| Il1r-1| IL-1R1| IL-1R-1| IL1RA| IL-1R-alpha| IL-1 receptor alpha chain| IL-1 receptor I| IL-1RT1| IL-1RT-1| IL-iR| interleukin 1 beta receptor type 1 short transmembrane form| interleukin 1 beta receptor type 1 soluble form| interleukin 1 bete receptor type 1 long transmembrane form| interleukin-1 receptor alpha| interleukin 1 receptor alpha, type I| interleukin 1 receptor, alpha; type I receptor| interleukin 1 receptor, type 1| Interleukin-1 receptor type 1| interleukin-1 receptor type 1-like protein| interleukin 1 receptor, type I| Interleukin-1 receptor type I| M91_02883| MDA_GLEAN10013325| N302_15256| N328_07650| N332_01794| N333_09765| N336_00938| N341_11137| P80| PAL_GLEAN10005835| PANDA_001347| il1r1

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