Summary of IL1R1
The gene codes for a protein, interleukin 1 receptor type 1. It is a regulator involved in several cytokine-induced immune and inflammatory responses [R].
The Function of IL1R1
Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.
Protein names
Recommended name:
Interleukin-1 receptor type 1Alternative name(s):
IL-1R-1IL-1RT-1
IL-1RT1
CD121 antigen-like family member A
Interleukin-1 receptor alpha
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD antigen CD121a
mIL-1R1
mIL-1RI
sIL-1R1
sIL-1RI
- RS12712127 (IL1R1) ??
- RS13019803 (IL1R1) ??
- RS1558643 (IL1R1) ??
- RS3917225 (IL1R1) ??
- RS3917265 (IL1R1) ??
- RS6759556 (IL1R1) ??
- RS949963 (IL1R1) ??
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Top Gene-Substance Interactions
IL1R1 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL1R1
| Substances | Interaction | Organism | Category |
Substances That Decrease IL1R1
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
- Interleukin-1, Type I, Activating Receptor Activity
- Interleukin-1 Receptor Activity
- Platelet-Derived Growth Factor Receptor Binding
- Signal Transducer Activity
- Transmembrane Signaling Receptor Activity
Biological Processes:
- Cell Surface Receptor Signaling Pathway
- Immune Response
- Interleukin-1-Mediated Signaling Pathway
- Positive Regulation Of Interleukin-1-Mediated Signaling Pathway
- Positive Regulation Of Neutrophil Extravasation
- Regulation Of Inflammatory Response
- Response To Interleukin-1
- Cellular Response To Glucose Stimulus
- Heat Acclimation
- Ovulation
- Response To Epidermal Growth Factor
- Response To Nitric Oxide
- Response To Radiation
- Response To Transforming Growth Factor Beta
Drug Bank:
- Anakinra