Summary of IL18
This gene encodes a proinflammatory cytokine that increases natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells (R).
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The Function of IL18
Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.
Protein names
Recommended name:
Interleukin-18Short name:
IL-18Alternative name(s):
IboctadekinInterferon gamma-inducing factor
IFN-gamma-inducing factor
Interleukin-1 gamma
IL-1 gamma
- RS1834481 (IL18) ??
- RS187238 (IL18) ??
- RS1946518 (IL18) ??
- RS1946519 (IL18) ??
- RS360717 (IL18) ??
- RS360718 (IL18) ??
- RS360719 (IL18) ??
- RS360722 (IL18) ??
- RS549908 (IL18) ??
- RS5744247 (IL18) ??
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Top Gene-Substance Interactions
IL18 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL18
| Substances | Interaction | Organism | Category |
Substances That Decrease IL18
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Activation Of Protein Kinase B Activity
- Angiogenesis
- Cell-Cell Signaling
- Cellular Response To Organic Cyclic Compound
- Chemokine Biosynthetic Process
- Cholesterol Homeostasis
- Granulocyte Macrophage Colony-Stimulating Factor Biosynthetic Process
- Immune Response
- Inflammatory Response
- Interferon-Gamma Biosynthetic Process
- Interleukin-13 Biosynthetic Process
- Interleukin-18-Mediated Signaling Pathway
- Interleukin-2 Biosynthetic Process
- Lipopolysaccharide-Mediated Signaling Pathway
- Mapk Cascade
- Natural Killer Cell Activation
- Negative Regulation Of Myoblast Differentiation
- Positive Regulation Of Activated T Cell Proliferation
- Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Interferon-Gamma Production
- Positive Regulation Of Interleukin-17 Production
- Positive Regulation Of Macrophage Derived Foam Cell Differentiation
- Positive Regulation Of Natural Killer Cell Proliferation
- Positive Regulation Of Nf-Kappab Import Into Nucleus
- Positive Regulation Of Nk T Cell Proliferation
- Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
- Positive Regulation Of Protein Kinase B Signaling
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of T-Helper 2 Cell Differentiation
- Positive Regulation Of Tissue Remodeling
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Regulation Of Cell Adhesion
- Sleep
- T-Helper 1 Type Immune Response
- Triglyceride Homeostasis
- Type 2 Immune Response
- Positive Regulation Of Gene Expression