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  3. IL18

IL18 (Interleukin 18)

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Summary of IL18

This gene encodes a proinflammatory cytokine that increases natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells (R). 

0 users want this gene increased, 0 users want it decreased

The Function of IL18

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Protein names

Recommended name:

Interleukin-18

Short name:

IL-18

Alternative name(s):

Iboctadekin
Interferon gamma-inducing factor
IFN-gamma-inducing factor
Interleukin-1 gamma
IL-1 gamma

IL18 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1834481 (IL18) ??
  2. RS187238 (IL18) ??
  3. RS1946518 (IL18) ??
  4. RS1946519 (IL18) ??
  5. RS360717 (IL18) ??
  6. RS360718 (IL18) ??
  7. RS360719 (IL18) ??
  8. RS360722 (IL18) ??
  9. RS549908 (IL18) ??
  10. RS5744247 (IL18) ??

Top Gene-Substance Interactions

IL18 Interacts with These Diseases

Disease Score

Substances That Increase IL18

Substances Interaction Organism Category

Substances That Decrease IL18

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • AP-1
  • c-Jun
  • NF-kappaB1
  • IRF-1
  • STAT1
  • STAT1beta
  • STAT1alpha
  • GATA-3
  • p300

Gene Pathways:

  • Rheumatoid arthritis
  • Immune System
  • Cytokine-cytokine receptor interaction
  • NOD-like receptor signaling pathway
  • Malaria
  • Tuberculosis
  • Cytosolic DNA-sensing pathway
  • African trypanosomiasis

Molecular Function:

  • Cytokine Activity

Biological Processes:

  • Activation Of Protein Kinase B Activity
  • Angiogenesis
  • Cell-Cell Signaling
  • Cellular Response To Organic Cyclic Compound
  • Chemokine Biosynthetic Process
  • Cholesterol Homeostasis
  • Granulocyte Macrophage Colony-Stimulating Factor Biosynthetic Process
  • Immune Response
  • Inflammatory Response
  • Interferon-Gamma Biosynthetic Process
  • Interleukin-13 Biosynthetic Process
  • Interleukin-18-Mediated Signaling Pathway
  • Interleukin-2 Biosynthetic Process
  • Lipopolysaccharide-Mediated Signaling Pathway
  • Mapk Cascade
  • Natural Killer Cell Activation
  • Negative Regulation Of Myoblast Differentiation
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-17 Production
  • Positive Regulation Of Macrophage Derived Foam Cell Differentiation
  • Positive Regulation Of Natural Killer Cell Proliferation
  • Positive Regulation Of Nf-Kappab Import Into Nucleus
  • Positive Regulation Of Nk T Cell Proliferation
  • Positive Regulation Of Phosphatidylinositol 3-Kinase Signaling
  • Positive Regulation Of Protein Kinase B Signaling
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of T-Helper 2 Cell Differentiation
  • Positive Regulation Of Tissue Remodeling
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
  • Regulation Of Cell Adhesion
  • Sleep
  • T-Helper 1 Type Immune Response
  • Triglyceride Homeostasis
  • Type 2 Immune Response
  • Positive Regulation Of Gene Expression
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_14350| AS27_14017| AS28_06508| CB1_000126002| ChIL-18| H920_17906| iboctadekin| IFN-gamma-inducing factor| IGIF| IL-18| IL1F4| IL-1g| IL-1 gamma| Interferon gamma-inducing factor| interleukin-18| interleukin 18 (interferon-gamma-inducing factor)| interleukin-18 isoform 1 proprotein| interleukin-18-like protein| interleukin-18 proprotein| interleukin-1 gamma| M959_13929| N300_14318| N301_02261| N302_11145| N303_11341| N305_04138| N306_01931| N307_03105| N308_07193| N309_09844| N310_00798| N311_00994| N312_07988| N320_09758| N321_10003| N322_11040| N324_00083| N325_09497| N326_09381| N327_11775| N328_08384| N329_10273| N330_08330| N331_08281| N332_09574| N333_09200| N334_12768| N335_12692| N336_00278| N339_09688| N340_12045| N341_00751| PAL_GLEAN10009107| PANDA_009974| TREES_T100013195| UY3_07714| Y1Q_005008| Y956_12617| Z169_08832| il18

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