Summary of IL16
This gene encodes a protein that functions as a modulator of T cell activation, and it also inhibits HIV replication (R).
The Function of IL16
Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Protein names
Recommended name:
Pro-interleukin-16 [Cleaved into: Interleukin-16Short name:
LCFAlternative name(s):
IL-16Lymphocyte chemoattractant factor
- RS1131445 (IL16) ??
- RS11556218 (IL16) ??
- RS3848180 (IL16) ??
- RS4072111 (IL16) ??
- RS4778889 (IL16) ??
- RS7172689 (IL16) ??
- RS8034928 (IL16) ??
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Top Gene-Substance Interactions
IL16 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL16
| Substances | Interaction | Organism | Category |
Substances That Decrease IL16
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.
Induction:
Isoform 3 is down-regulated in T-cells after TCR activation.
Biological Processes:
- Transcription, Dna-Templated
- Regulation Of Transcription, Dna-Templated
- Immune Response
- Viral Process
- Leukocyte Chemotaxis
- Induction Of Positive Chemotaxis