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  3. IL16

IL16 (Interleukin 16)

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Summary of IL16

This gene encodes a protein that functions as a modulator of T cell activation, and it also inhibits HIV replication (R). 

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The Function of IL16

Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Protein names

Recommended name:

Pro-interleukin-16 [Cleaved into: Interleukin-16

Short name:

LCF

Alternative name(s):

IL-16
Lymphocyte chemoattractant factor

IL16 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1131445 (IL16) ??
  2. RS11556218 (IL16) ??
  3. RS3848180 (IL16) ??
  4. RS4072111 (IL16) ??
  5. RS4778889 (IL16) ??
  6. RS7172689 (IL16) ??
  7. RS8034928 (IL16) ??

Top Gene-Substance Interactions

IL16 Interacts with These Diseases

Disease Score

Substances That Increase IL16

Substances Interaction Organism Category

Substances That Decrease IL16

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT1
  • STAT1beta
  • STAT1alpha
  • GATA-3

Tissue specificity:

Isoform 3 is expressed in hemopoietic tissues, such as resting T-cells, but is undetectable during active T-cell proliferation.

Induction:

Isoform 3 is down-regulated in T-cells after TCR activation.

Biological Processes:

  • Immune Response
  • Induction Of Positive Chemotaxis
  • Leukocyte Chemotaxis
  • Regulation Of Transcription, Dna-Templated
  • Transcription, Dna-Templated
  • Viral Process
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_15022| AS27_00148| AS28_07820| CB1_001254005| H920_04016| I79_021660| IL-16| interleukin-16| interleukin 16 (lymphocyte chemoattractant factor)| LCF| lymphocyte chemoattractant factor| M91_03827| M959_09786| N300_13789| N301_09107| N302_16280| N303_08846| N305_00726| N306_10274| N307_02707| N308_02687| N309_00420| N310_03807| N320_12627| N321_01884| N322_03333| N324_09700| N325_02783| N326_02041| N327_09884| N328_08371| N329_04418| N330_07728| N332_14280| N333_02137| N334_13019| N335_11063| N339_05854| N340_07788| N341_03332| neuronal interleukin 16| NIL16| PAL_GLEAN10009564| PANDA_007715| prIL-16| PRIL16| pro-interleukin-16| prointerleukin 16| pro-interleukin-16-like protein| TREES_T100016714| UY3_13752| Y1Q_023253| Y956_09761| Z169_06759| il16

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