Summary of IL15
The gene codes for a protein, interleukin 15. It regulates T and natural killer cell activation and proliferation [R].
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The Function of IL15
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Protein names
Recommended name:
Interleukin-15Short name:
IL-15- RS10519612 (IL15) ??
- RS10519613 (IL15) ??
- RS10833 (IL15) ??
- RS17007695 (IL15) ??
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Top Gene-Substance Interactions
IL15 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL15
| Substances | Interaction | Organism | Category |
Substances That Decrease IL15
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Most abundant in placenta and skeletal muscle. It is also detected in the heart, lung, liver and kidney. IL15-S21AA is preferentially expressed in tissues such as testis and thymus.
Gene Pathways:
Molecular Function:
Biological Processes:
- Natural Killer Cell Differentiation
- Nk T Cell Proliferation
- Inflammatory Response
- Immune Response
- Signal Transduction
- Cell-Cell Signaling
- Aging
- Positive Regulation Of Cell Proliferation
- Skeletal Muscle Atrophy
- Hyaluronan Metabolic Process
- Positive Regulation Of Interleukin-17 Production
- Positive Regulation Of Natural Killer Cell Proliferation
- Positive Regulation Of Natural Killer Cell Differentiation
- Positive Regulation Of Tissue Remodeling
- Positive Regulation Of T Cell Proliferation
- Tyrosine Phosphorylation Of Stat5 Protein
- Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
- Extrathymic T Cell Selection
- Regulation Of T Cell Differentiation
- Cell Maturation
- Lymph Node Development
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Regulation Of Defense Response To Virus By Host
- Positive Regulation Of Inflammatory Response
- Positive Regulation Of Immune Response
- Cellular Response To Vitamin D
- Positive Regulation Of Protein O-Linked Glycosylation