• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. IL13

IL13 (Interleukin 13)

Loading...

Summary of IL13

This gene encodes a cytokine that inhibits the production of pro-inflammatory cytokines and chemokines (R).

IL-13 is part of the Th2 immune arm.

0 users want this gene increased, 0 users want it decreased

The Function of IL13

Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages.

Protein names

Recommended name:

Interleukin-13

Short name:

IL-13

IL13 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12188917 (IL13) ??
  2. RS1295685 (IL13) ??
  3. RS1295686 (IL13) ??
  4. RS1800925 (IL13) ??
  5. RS1881457 (IL13) ??
  6. RS20541 (IL13) ??
  7. RS2066960 (IL13) ??
  8. RS2069757 (IL13) ??
  9. RS3091307 (IL13) ??
  10. RS848 (IL13) ??

Top Gene-Substance Interactions

IL13 Interacts with These Diseases

Disease Score

Substances That Increase IL13

Substances Interaction Organism Category

Substances That Decrease IL13

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: psoriatic arthritisFrom NCBI Gene: Asthma, susceptibility toAllergic rhinitisFrom UniProt: Allergic rhinitis (ALRH): A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. [MIM:607154]

     From NCBI Gene: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] From UniProt: Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • GR
  • GR-alpha
  • GR-beta
  • AP-1
  • c-Jun
  • STAT1beta
  • STAT1alpha
  • GATA-3
  • NF-AT2

Gene Pathways:

  • Cytokine-cytokine receptor interaction
  • Jak-STAT signaling pathway
  • Measles
  • Asthma
  • Fc epsilon RI signaling pathway

Caution:

It is uncertain whether Met-1 or Met-15 is the initiator.

Molecular Function:

  • Cytokine Activity
  • Interleukin-13 Receptor Binding

Biological Processes:

  • Cell-Cell Signaling
  • Cellular Response To Cytokine Stimulus
  • Cellular Response To Mechanical Stimulus
  • Immune Response
  • Inflammatory Response
  • Microglial Cell Activation
  • Movement Of Cell Or Subcellular Component
  • Negative Regulation Of Complement-Dependent Cytotoxicity
  • Negative Regulation Of Endothelial Cell Apoptotic Process
  • Negative Regulation Of Lung Ciliated Cell Differentiation
  • Negative Regulation Of Nad(P)H Oxidase Activity
  • Negative Regulation Of Neuron Death
  • Negative Regulation Of Transforming Growth Factor Beta Production
  • Positive Regulation Of B Cell Proliferation
  • Positive Regulation Of Connective Tissue Growth Factor Production
  • Positive Regulation Of Immunoglobulin Production
  • Positive Regulation Of Lung Goblet Cell Differentiation
  • Positive Regulation Of Macrophage Activation
  • Positive Regulation Of Mast Cell Degranulation
  • Positive Regulation Of Pancreatic Stellate Cell Proliferation
  • Positive Regulation Of Protein Secretion
  • Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
  • Positive Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein
  • Regulation Of Proton Transport
  • Response To Ethanol
  • Response To Lipopolysaccharide
  • Response To Nicotine
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| CB1_000434003| D623_10032560| IL-13| IL-4| il4/13a| Interleukin-13| interleukin 4/13A| L13| MDA_GLEAN10009171| P600| PAL_GLEAN10016892| PANDA_000729| T-cell activation protein P600| TREES_T100018904| il13

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved