Summary of IL13
The IL13 gene encodes interleukin-13, an important inflammatory marker [R].
IL-13 is generally an anti-inflammatory cytokine. It blocks the production of proinflammatory cytokines and interferon-gamma (IFN-γ). IL-13 is mostly produced by Th2 cells [R, R].
Variants in IL13 have been linked to [R, R, R]:
- Breast cancer
- Asthma
- Atopic dermatitis
Protein names
Recommended name:
Interleukin-13Short name:
IL-13- RS12188917 (IL13) ??
- RS1295685 (IL13) ??
- RS1295686 (IL13) ??
- RS1800925 (IL13) ??
- RS1881457 (IL13) ??
- RS20541 (IL13) ??
- RS2066960 (IL13) ??
- RS2069757 (IL13) ??
- RS3091307 (IL13) ??
- RS848 (IL13) ??
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Top Gene-Substance Interactions
IL13 Interacts with These Diseases
| Disease | Score |
Substances That Increase IL13
| Substances | Interaction | Organism | Category |
Substances That Decrease IL13
| Substances | Interaction | Organism | Category |
Advanced Summary
Covered on Genetics Home Reference: psoriatic arthritisFrom NCBI Gene: Asthma, susceptibility toAllergic rhinitisFrom UniProt: Allergic rhinitis (ALRH): A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure. [MIM:607154]
From NCBI Gene: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008] From UniProt: Cytokine (PubMed:8096327, PubMed:8097324). Inhibits inflammatory cytokine production (PubMed:8096327). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). May be critical in regulating inflammatory and immune responses (PubMed:8096327, PubMed:8097324). Positively regulates IL31RA expression in macrophages.
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Caution:
It is uncertain whether Met-1 or Met-15 is the initiator.
Molecular Function:
Biological Processes:
- Microglial Cell Activation
- Positive Regulation Of Immunoglobulin Production
- Movement Of Cell Or Subcellular Component
- Inflammatory Response
- Immune Response
- Signal Transduction
- Cell-Cell Signaling
- Regulation Of Proton Transport
- Positive Regulation Of B Cell Proliferation
- Response To Lipopolysaccharide
- Positive Regulation Of Connective Tissue Growth Factor Production
- Negative Regulation Of Nad(P)H Oxidase Activity
- Response To Nicotine
- Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein
- Positive Regulation Of Macrophage Activation
- Positive Regulation Of Mast Cell Degranulation
- Response To Ethanol
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Protein Secretion
- Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
- Cellular Response To Mechanical Stimulus
- Cellular Response To Cytokine Stimulus
- Negative Regulation Of Transforming Growth Factor Beta Production
- Negative Regulation Of Neuron Death
- Negative Regulation Of Lung Ciliated Cell Differentiation
- Positive Regulation Of Lung Goblet Cell Differentiation
- Negative Regulation Of Complement-Dependent Cytotoxicity
- Positive Regulation Of Pancreatic Stellate Cell Proliferation
- Negative Regulation Of Endothelial Cell Apoptotic Process