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  3. IL12B

IL12B (Interleukin 12B)

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Summary of IL12B

This gene encodes a subunit of interleukin 12. Interleukin 12 is a cytokine that acts on T and natural killer cells, and also helps sustain a sufficient number of Th1 cells to keep long-term protection against pathogens (R). 

Overexpression of this gene was observed in patients with multiple sclerosis and a polymorphism of this gene is associated with asthma in children (R). 

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The Function of IL12B

Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Protein names

Recommended name:

Interleukin-12 subunit beta

Short name:

NKSF2

Alternative name(s):

IL-12B
Cytotoxic lymphocyte maturation factor 40 kDa subunit
CLMF p40
IL-12 subunit p40
NK cell stimulatory factor chain 2

IL12B SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS2288831 (IL12B) ??
  2. RS2853694 (IL12B) ??
  3. RS3181224 (IL12B) ??
  4. RS3212220 (IL12B) ??
  5. RS3212227 (IL12B) ??
  6. RS3213094 (IL12B) ??
  7. RS3213119 (IL12B) ??

Top Gene-Substance Interactions

IL12B Interacts with These Diseases

Disease Score

Substances That Increase IL12B

Substances Interaction Organism Category

Substances That Decrease IL12B

Substances Interaction Organism Category

Advanced Summary

     Covered on Genetics Home Reference: psoriatic arthritisFrom NCBI Gene: Immunodeficiency 29From UniProt: Psoriasis 11 (PSORS11): A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. [MIM:612599] Immunodeficiency 29 (IMD29): A form of Mendelian susceptibility to mycobacterial disease, a rare condition caused by impairment of interferon-gamma mediated immunity. It is characterized by predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine, environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. Clinical outcome severity depends on the degree of impairment of interferon-gamma mediated immunity. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. IMD29 is characterized by undetectable IL12B secretion from leukocytes. Affected individuals generally present with BCG disease after vaccination in childhood, and at least half also have Salmonella infection. Disease phenotype is relatively mild, and patients have a good prognosis. [MIM:614890]

     From NCBI Gene: This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008] From UniProt: Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • STAT1
  • TBP
  • STAT1beta
  • STAT1alpha
  • TFIID

Gene Pathways:

  • Measles
  • Cytokine-cytokine receptor interaction
  • Amoebiasis
  • Chagas disease (American trypanosomiasis)
  • Tuberculosis
  • Toxoplasmosis
  • Jak-STAT signaling pathway
  • Leishmaniasis
  • Toll-like receptor signaling pathway
  • Allograft rejection
  • RIG-I-like receptor signaling pathway
  • Type I diabetes mellitus
  • African trypanosomiasis

Molecular Function:

  • Cytokine Receptor Activity
  • Interleukin-12 Alpha Subunit Binding
  • Interleukin-12 Receptor Binding
  • Protein Heterodimerization Activity
  • Identical Protein Binding

Biological Processes:

  • Cell Cycle Arrest
  • Cellular Response To Interferon-Gamma
  • Cellular Response To Lipopolysaccharide
  • Defense Response To Gram-Negative Bacterium
  • Defense Response To Protozoan
  • Defense Response To Virus
  • Interferon-Gamma Biosynthetic Process
  • Natural Killer Cell Activation
  • Natural Killer Cell Activation Involved In Immune Response
  • Negative Regulation Of Growth Of Symbiont In Host
  • Negative Regulation Of Inflammatory Response To Antigenic Stimulus
  • Negative Regulation Of Interleukin-10 Production
  • Negative Regulation Of Interleukin-17 Production
  • Negative Regulation Of Smooth Muscle Cell Proliferation
  • Positive Regulation Of Activated T Cell Proliferation
  • Positive Regulation Of Activation Of Jak2 Kinase Activity
  • Positive Regulation Of Cell Adhesion
  • Positive Regulation Of Defense Response To Virus By Host
  • Positive Regulation Of Granulocyte Macrophage Colony-Stimulating Factor Production
  • Positive Regulation Of Inflammatory Response
  • Positive Regulation Of Interferon-Gamma Biosynthetic Process
  • Positive Regulation Of Interferon-Gamma Production
  • Positive Regulation Of Interleukin-10 Production
  • Positive Regulation Of Interleukin-12 Production
  • Positive Regulation Of Interleukin-17 Production
  • Positive Regulation Of Lymphocyte Proliferation
  • Positive Regulation Of Memory T Cell Differentiation
  • Positive Regulation Of Mononuclear Cell Proliferation
  • Positive Regulation Of Natural Killer Cell Activation
  • Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
  • Positive Regulation Of Natural Killer Cell Proliferation
  • Positive Regulation Of Nf-Kappab Import Into Nucleus
  • Positive Regulation Of Nk T Cell Activation
  • Positive Regulation Of Nk T Cell Proliferation
  • Positive Regulation Of Osteoclast Differentiation
  • Positive Regulation Of Smooth Muscle Cell Apoptotic Process
  • Positive Regulation Of T Cell Mediated Cytotoxicity
  • Positive Regulation Of T Cell Proliferation
  • Positive Regulation Of T-Helper 17 Cell Lineage Commitment
  • Positive Regulation Of T-Helper 17 Type Immune Response
  • Positive Regulation Of T-Helper 1 Type Immune Response
  • Positive Regulation Of Tissue Remodeling
  • Positive Regulation Of Tumor Necrosis Factor Production
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
  • Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein
  • Regulation Of Cytokine Biosynthetic Process
  • Regulation Of Tyrosine Phosphorylation Of Stat1 Protein
  • Response To Uv-B
  • Sensory Perception Of Pain
  • Sexual Reproduction
  • T-Helper 1 Type Immune Response
  • T-Helper Cell Differentiation

Drug Bank:

  • Ustekinumab
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| IMD28| CLMF| A306_14613| AS27_11875| AS28_10281| CB1_000339014| CLMF2| CLMF p40| Cytotoxic lymphocyte maturation factor 40 kDa subunit| D623_10034839| GW7_01291| H920_04507| Il12| IL-12| IL-12B| IL12p40| IL-12p40| IL-12 p40| IL-12.p40| IL-12 p40 subunit| IL-12 subunit p40| IL12, subunit p40| IL-23 subunit p40| IMD29| interleukin-12| interleukin 12 40kDa subunit| interleukin-12 alpha p40 subunit| interleukin 12 beta| interleukin-12 beta chain| interleukin 12 beta chain precursor| interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)| interleukin 12p40| interleukin 12, p40| interleukin-12p40| interleukin-12 p40| interleukin-12 p40 chain| interleukin 12 p40 subunit| interleukin-12 p40 subunit| interleukin-12 subunit beta| interleukin 12 subunit p40| interleukin 23 p40 subunit| interleukin-23 p40 subunit| M959_08298| MDA_GLEAN10025735| N300_13061| N302_05379| N303_08867| N305_05814| N306_14472| N307_13816| N309_14274| N310_04503| N311_06726| N321_13890| N322_12202| N324_03510| N325_02519| N326_03370| N327_09629| N328_09682| N329_12360| N330_12379| N331_09463| N332_09304| N333_08989| N335_01108| N339_05387| N340_12843| N341_02074| natural killer cell stimulatory factor, 40 kD subunit| NK cell stimulatory factor chain 2| NKSF| NKSF2| p40| PAL_GLEAN10018830| PANDA_000311| TREES_T100004776| Y1Q_021366| Y956_04346| il12b

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