The Function of IHH
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
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Protein names
Recommended name:
Indian hedgehog proteinShort name:
IHHAlternative name(s):
HHG-2- RS1052483 (IHH) ??
- RS12470505 (IHH) ??
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Top Gene-Substance Interactions
IHH Interacts with These Diseases
| Disease | Score |
Substances That Increase IHH
| Substances | Interaction | Organism | Category |
Substances That Decrease IHH
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in embryonic lung, and in adult kidney and liver.
Gene Pathways:
Molecular Function:
Biological Processes:
- Cartilage Development
- Cell-Cell Signaling
- Embryonic Digit Morphogenesis
- Heart Looping
- Intein-Mediated Protein Splicing
- Maternal Process Involved In Female Pregnancy
- Negative Regulation Of Alpha-Beta T Cell Differentiation
- Negative Regulation Of Apoptotic Process
- Negative Regulation Of Immature T Cell Proliferation In Thymus
- Negative Regulation Of Signal Transduction
- Negative Regulation Of T Cell Differentiation In Thymus
- Positive Regulation Of Alpha-Beta T Cell Differentiation
- Positive Regulation Of Chondrocyte Differentiation
- Positive Regulation Of Epithelial Cell Proliferation
- Positive Regulation Of Smoothened Signaling Pathway
- Positive Regulation Of T Cell Differentiation In Thymus
- Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
- Response To Estradiol
- Skeletal System Development
- Smoothened Signaling Pathway
- Somite Development