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IHH (Indian hedgehog)

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The Function of IHH

Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).

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Protein names

Recommended name:

Indian hedgehog protein

Short name:

IHH

Alternative name(s):

HHG-2

IHH SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS1052483 (IHH) ??
  2. RS12470505 (IHH) ??

Top Gene-Substance Interactions

IHH Interacts with These Diseases

Disease Score

Substances That Increase IHH

Substances Interaction Organism Category

Substances That Decrease IHH

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ARP-1
  • Sox9
  • ITF-2
  • CUTL1
  • STAT1
  • STAT1alpha
  • STAT1beta

Tissue specificity:

Expressed in embryonic lung, and in adult kidney and liver.

Gene Pathways:

  • Signal Transduction
  • Hedgehog signaling pathway
  • Disease

Molecular Function:

  • Patched Binding
  • Calcium Ion Binding
  • Peptidase Activity

Biological Processes:

  • Skeletal System Development
  • Heart Looping
  • Smoothened Signaling Pathway
  • Cell-Cell Signaling
  • Negative Regulation Of Signal Transduction
  • Intein-Mediated Protein Splicing
  • Positive Regulation Of Chondrocyte Differentiation
  • Response To Estradiol
  • Negative Regulation Of T Cell Differentiation In Thymus
  • Negative Regulation Of Immature T Cell Proliferation In Thymus
  • Positive Regulation Of T Cell Differentiation In Thymus
  • Embryonic Digit Morphogenesis
  • Negative Regulation Of Apoptotic Process
  • Positive Regulation Of Smoothened Signaling Pathway
  • Positive Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Positive Regulation Of Alpha-Beta T Cell Differentiation
  • Negative Regulation Of Alpha-Beta T Cell Differentiation
  • Positive Regulation Of Epithelial Cell Proliferation
  • Cartilage Development
  • Maternal Process Involved In Female Pregnancy
  • Somite Development
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07465| Anapl_10118| AS27_06730| banded hedgehog| BDA1| bhh| CB1_000931053| D623_10032923| GW7_07290| hedgehog| HHG2| HHG-2| Indian hedgehog homolog| Indian hedgehog-like protein| Indian hedgehog protein| M91_13944| M959_07089| MDA_GLEAN10022941| N300_03562| N301_00300| N302_11632| N303_03676| N307_04372| N320_09342| N330_08205| N333_07641| N340_06737| PAL_GLEAN10014410| PANDA_001534| Xbhh| X-BHH| X-hh| Y956_16293| ihh

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