The Function of IGSF8
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
Protein names
Recommended name:
Immunoglobulin superfamily member 8Short name:
PGRLAlternative name(s):
IgSF8CD81 partner 3
Glu-Trp-Ile EWI motif-containing protein 2
EWI-2
Keratinocytes-associated transmembrane protein 4
KCT-4
LIR-D1
Prostaglandin regulatory-like protein
CD antigen CD316
- RS6688363 (IGSF8) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
Substances That Increase IGSF8
| Substances | Interaction | Organism | Category |
Substances That Decrease IGSF8
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
Biological Processes:
- Cell Proliferation
- Movement Of Cell Or Subcellular Component
- Nervous System Development
- Single Fertilization
- Skeletal Muscle Tissue Development