• Navigation
  • Register My DNA Kit
  • Features
  • Pricing
  • FAQ
  • About
  • Labs
  • Login
  • Get started
  1. Home
  2. Genes
  3. IGFBP3

IGFBP3 (Insulin like growth factor binding protein 3)

Loading...

Summary of IGFBP3

IGFBP3 (insulin like growth factor binding protein 3) encodes a protein that forms a complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor 1 or 2 (R). 

Polymorphisms of this can cause cancer (R). 

0 users want this gene increased, 0 users want it decreased

The Function of IGFBP3

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Protein names

Recommended name:

Insulin-like growth factor-binding protein 3

Short name:

IBP-3

Alternative name(s):

IGF-binding protein 3
IGFBP-3

IGFBP3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS13223993 (IGFBP3) ??
  2. RS2132570 (IGFBP3) ??
  3. RS2453839 (IGFBP3) ??
  4. RS2471551 (IGFBP3) ??
  5. RS2854744 (IGFBP3) ??
  6. RS2854746 (IGFBP3) ??
  7. RS3110697 (IGFBP3) ??

Top Gene-Substance Interactions

IGFBP3 Interacts with These Diseases

Disease Score

Substances That Increase IGFBP3

Substances Interaction Organism Category

Substances That Decrease IGFBP3

Substances Interaction Organism Category

Advanced Summary

IGFBP3 (insulin like growth factor binding protein 3) encodes a protein that forms a complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor 1 or 2 (R). 

Polymorphisms of this can cause cancer (R). 

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • PPAR-gamma1
  • p53
  • STAT5B
  • Sp1
  • STAT1
  • TBP
  • STAT1beta
  • STAT1alpha
  • AML1a
  • TFIID

Tissue specificity:

Expressed by most tissues. Present in plasma.

Gene Pathways:

  • Metabolism of proteins
  • p53 signaling pathway

Induction:

Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.

Developmental stage:

IGFBP3 levels are higher during extrauterine life and peak during puberty.

Molecular Function:

  • Fibronectin Binding
  • Insulin-Like Growth Factor Binding
  • Insulin-Like Growth Factor I Binding
  • Insulin-Like Growth Factor Ii Binding
  • Metal Ion Binding
  • Protein Tyrosine Phosphatase Activator Activity

Biological Processes:

  • Apoptotic Process
  • Cellular Protein Metabolic Process
  • Negative Regulation Of Cell Proliferation
  • Negative Regulation Of Protein Phosphorylation
  • Negative Regulation Of Signal Transduction
  • Negative Regulation Of Smooth Muscle Cell Migration
  • Negative Regulation Of Smooth Muscle Cell Proliferation
  • Osteoblast Differentiation
  • Positive Regulation Of Apoptotic Process
  • Positive Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
  • Positive Regulation Of Mapk Cascade
  • Positive Regulation Of Myoblast Differentiation
  • Protein Phosphorylation
  • Regulation Of Apoptotic Process
  • Regulation Of Cell Growth
  • Regulation Of Glucose Metabolic Process
  • Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
  • Type B Pancreatic Cell Proliferation

Drug Bank:

  • Mecasermin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

A306_09477| acid stable subunit of the 140 K IGF complex| Anapl_16960| AS27_10560| AS28_08801| binding protein 29| binding protein 53| BP-53| CB1_000255002| D623_10014874| growth hormone-dependent binding protein| H920_05659| I79_011450| IBP3| IBP-3| IGF-binding protein 3| IGF-BP3| IGFBP-3| IGgfbp3| insulin-like growth factor binding protein 3| insulin-like growth factor-binding protein 3| Insulin like growth factor binding protein-3| insulin-like growth factor-binding protein (IGF-BP3)| M959_13220| MDA_GLEAN10006474| N300_15298| N301_00237| N303_08884| N305_01780| N306_02988| N307_01733| N308_16120| N309_03233| N310_10666| N312_08913| N320_10607| N321_03588| N322_11102| N324_07061| N325_00184| N326_09004| N327_09601| N328_07850| N330_11528| N331_08647| N332_08490| N333_05926| N334_10748| N335_13809| N336_02075| N339_09135| N340_11652| N341_06524| PAL_GLEAN10002299| PANDA_012349| UY3_08517| Y1Q_021612| Y956_14740| Z169_02653| igfbp3

Policies

  • Terms of Service
  • Platform Consent
  • Privacy Policy
  • Disclaimer

About

  • Customer Support
  • Our Team
  • Affiliate Program

Navigation

  • Homepage
  • DNA Wellness Reports
  • Personalized Genetics Blog
  • Register your DNA Test Kit
  • Login
  • Careers
GET STARTED
  • SelfDecode is a personalized health report service, which enables users to obtain detailed information and reports based on their genome. SelfDecode does not treat, diagnose or cure any conditions, but is for informational and educational purposes alone.
SelfDecode © 2021 All Rights Reserved