Summary of IGFBP3
IGFBP3 (insulin like growth factor binding protein 3) encodes a protein that forms a complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor 1 or 2 (R).
Polymorphisms of this can cause cancer (R).
The Function of IGFBP3
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.
Protein names
Recommended name:
Insulin-like growth factor-binding protein 3Short name:
IBP-3Alternative name(s):
IGF-binding protein 3IGFBP-3
- RS13223993 (IGFBP3) ??
- RS2132570 (IGFBP3) ??
- RS2453839 (IGFBP3) ??
- RS2471551 (IGFBP3) ??
- RS2854744 (IGFBP3) ??
- RS2854746 (IGFBP3) ??
- RS3110697 (IGFBP3) ??
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Top Gene-Substance Interactions
IGFBP3 Interacts with These Diseases
| Disease | Score |
Substances That Increase IGFBP3
| Substances | Interaction | Organism | Category |
Substances That Decrease IGFBP3
| Substances | Interaction | Organism | Category |
Advanced Summary
IGFBP3 (insulin like growth factor binding protein 3) encodes a protein that forms a complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor 1 or 2 (R).
Polymorphisms of this can cause cancer (R).
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed by most tissues. Present in plasma.
Gene Pathways:
Induction:
Up-regulated in the presence of IGF1, insulin and other growth-stimulating factors such as growth hormone, EGF and phorbol esters.
Developmental stage:
IGFBP3 levels are higher during extrauterine life and peak during puberty.
Molecular Function:
- Fibronectin Binding
- Insulin-Like Growth Factor Binding
- Insulin-Like Growth Factor I Binding
- Insulin-Like Growth Factor Ii Binding
- Metal Ion Binding
- Protein Tyrosine Phosphatase Activator Activity
Biological Processes:
- Apoptotic Process
- Cellular Protein Metabolic Process
- Negative Regulation Of Cell Proliferation
- Negative Regulation Of Protein Phosphorylation
- Negative Regulation Of Signal Transduction
- Negative Regulation Of Smooth Muscle Cell Migration
- Negative Regulation Of Smooth Muscle Cell Proliferation
- Osteoblast Differentiation
- Positive Regulation Of Apoptotic Process
- Positive Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
- Positive Regulation Of Mapk Cascade
- Positive Regulation Of Myoblast Differentiation
- Protein Phosphorylation
- Regulation Of Apoptotic Process
- Regulation Of Cell Growth
- Regulation Of Glucose Metabolic Process
- Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
- Type B Pancreatic Cell Proliferation