The Function of IGFBP2
Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
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- RS9288520 (IGFBP2) ??
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Top Gene-Substance Interactions
IGFBP2 Interacts with These Diseases
| Disease | Score |
Substances That Increase IGFBP2
| Substances | Interaction | Organism | Category |
Substances That Decrease IGFBP2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Molecular Function:
Biological Processes:
- Aging
- Cellular Protein Metabolic Process
- Cellular Response To Hormone Stimulus
- Female Pregnancy
- Negative Regulation Of Canonical Wnt Signaling Pathway
- Positive Regulation Of Activated T Cell Proliferation
- Regulation Of Cell Growth
- Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
- Response To Estradiol
- Response To Estrogen
- Response To Glucocorticoid
- Response To Lithium Ion
- Response To Mechanical Stimulus
- Response To Nutrient
- Response To Retinoic Acid
- Signal Transduction