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  3. IGFBP2

IGFBP2 (Insulin like growth factor binding protein 2)

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The Function of IGFBP2

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

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IGFBP2 SNPs

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  1. RS9288520 (IGFBP2) ??

Top Gene-Substance Interactions

IGFBP2 Interacts with These Diseases

Disease Score

Substances That Increase IGFBP2

Substances Interaction Organism Category

Substances That Decrease IGFBP2

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • NF-kappaB
  • STAT3
  • NF-kappaB1
  • HNF-4alpha1
  • HNF-4alpha2
  • STAT5A

Gene Pathways:

  • Metabolism of proteins

Molecular Function:

  • Insulin-Like Growth Factor I Binding
  • Insulin-Like Growth Factor Ii Binding
  • Receptor Binding

Biological Processes:

  • Aging
  • Cellular Protein Metabolic Process
  • Cellular Response To Hormone Stimulus
  • Female Pregnancy
  • Negative Regulation Of Canonical Wnt Signaling Pathway
  • Positive Regulation Of Activated T Cell Proliferation
  • Regulation Of Cell Growth
  • Regulation Of Insulin-Like Growth Factor Receptor Signaling Pathway
  • Response To Estradiol
  • Response To Estrogen
  • Response To Glucocorticoid
  • Response To Lithium Ion
  • Response To Mechanical Stimulus
  • Response To Nutrient
  • Response To Retinoic Acid
  • Signal Transduction
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_07435| AS28_13192| BRL-BP| CB1_000931022| D623_10032866| EH28_17791| H920_18481| I79_004989| IBP2| IBP-2| IGF binding protein 2| IGF-binding protein 2| IGFBP-2| igf-bp53| ILGFBPA| insulin-like growth factor binding protein 2| insulin-like growth factor-binding protein 2| insulin-like growth factor binding protein 2, 36kDa| Insulin-like growth factor-binding protein 2-A| insulin-like growth factor-binding protein-2, IGFBP-2| insulin-like growth factor binding protein-II| M91_13913| MDA_GLEAN10022901| mIGFBP-2| N300_03588| N301_09594| N302_10996| N303_03656| N305_07422| N307_04401| N310_01705| N320_02638| N321_06350| N322_04473| N324_12496| N327_08053| N328_06952| N329_02087| N330_07128| N331_04563| N332_05207| N333_05612| N334_04212| N335_03485| N336_08249| N339_11376| N340_08832| PAL_GLEAN10014449| PANDA_001568| pIGFBP-2| TREES_T100001907| Y1Q_013684| Y956_05818| Z169_15098| igfbp2

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