IGF2R (insulin like growth factor 2 receptor) encodes for a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. It helps the intracellular movement of lysosomal enzymes and degradation of insulin like growth factor 2 (R). 

Mutation of this gene can cause cancer (R). 

     From NCBI Gene: Hepatocellular carcinoma

     From NCBI Gene: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015] From UniProt: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2 . Acts as a positive regulator of T-cell coactivation, by binding DPP4.

The following transcription factors affect gene expression:

• USF1
• USF-1
• c-Jun
• AP-1
• ER-alpha
• c-Myc
• p53

Molecular Function:

• Glycoprotein Binding
• Retinoic Acid Binding
• Receptor Activity
• G-Protein Coupled Receptor Activity
• Insulin-Like Growth Factor-Activated Receptor Activity
• Transporter Activity
• Mannose Binding
• Identical Protein Binding
• Phosphoprotein Binding

Biological Processes:

• Liver Development
• Receptor-Mediated Endocytosis
• Signal Transduction
• Spermatogenesis
• Post-Embryonic Development
• Animal Organ Regeneration
• Response To Retinoic Acid
• Positive Regulation Of Apoptotic Process

Drug Bank:

• Mecasermin