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  3. IGF2R

IGF2R (Insulin like growth factor 2 receptor)

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Summary of IGF2R

IGF2R (insulin like growth factor 2 receptor) encodes for a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. It helps the intracellular movement of lysosomal enzymes and degradation of insulin like growth factor 2 (R). 

Mutation of this gene can cause cancer (R). 

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The Function of IGF2R

Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Protein names

Recommended name:

Cation-independent mannose-6-phosphate receptor

Short name:

M6PR

Alternative name(s):

CI Man-6-P receptor
CI-MPR
300 kDa mannose 6-phosphate receptor
MPR 300
Insulin-like growth factor 2 receptor
Insulin-like growth factor II receptor
IGF-II receptor
M6P/IGF2 receptor
M6P/IGF2R
CD antigen CD222

IGF2R SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS6917747 (IGF2R) ??
  2. RS78797168 (IGF2R) ??
  3. RS8191754 (IGF2R) ??
  4. RS998075 (IGF2R) ??

Top Gene-Substance Interactions

IGF2R Interacts with These Diseases

Disease Score

Substances That Increase IGF2R

Substances Interaction Organism Category

Substances That Decrease IGF2R

Substances Interaction Organism Category

Advanced Summary

IGF2R (insulin like growth factor 2 receptor) encodes for a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. It helps the intracellular movement of lysosomal enzymes and degradation of insulin like growth factor 2 (R). 

Mutation of this gene can cause cancer (R). 

     From NCBI Gene: Hepatocellular carcinoma

     From NCBI Gene: This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015] From UniProt: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2 . Acts as a positive regulator of T-cell coactivation, by binding DPP4.

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • ER-alpha
  • p53
  • AP-1
  • c-Jun
  • c-Myc
  • USF1
  • USF-1

Gene Pathways:

  • Lysosome
  • Membrane Trafficking

Molecular Function:

  • Glycoprotein Binding
  • G-Protein Coupled Receptor Activity
  • Insulin-Like Growth Factor-Activated Receptor Activity
  • Mannose Binding
  • Phosphoprotein Binding
  • Receptor Activity
  • Retinoic Acid Binding
  • Transporter Activity
  • Identical Protein Binding

Biological Processes:

  • Animal Organ Regeneration
  • Liver Development
  • Positive Regulation Of Apoptotic Process
  • Post-Embryonic Development
  • Receptor-Mediated Endocytosis
  • Response To Retinoic Acid
  • Signal Transduction
  • Spermatogenesis

Drug Bank:

  • Mecasermin
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 300 kDa mannose 6-phosphate receptor| A306_05596| AS28_07457| cation-independent mannose 6 phosphate receptor| cation-independent mannose 6-phosphate receptor| Cation-independent mannose-6-phosphate receptor| cation-independent MPR| CB1_000390048| CD222| CI-M6PR| CI Man-6-P receptor| cimpr| CI-MPR| H920_08191| I79_009791| IGF-II/CI-MPR| IGF-IIR| IGF-II receptor| Igfr2| insulin growth factor 2 receptor| insulin-like growth factor 2 receptor| insulin-like growth factor II receptor| insulin-like growth factor receptor II| insulin-like growth factor receptor type 2| insulin-like growth factor type II receptor| m6p/igf2r| M6P/IGF2 receptor| M6PR| M6P-R| M91_06284| M959_02381| mannose 6-phosphate/insulin-like growth factor 2 receptor| mannose-6-phosphate/insulin-like growth factor II receptor| mannose-6-phosphate receptor, cation independent| MDA_GLEAN10018866| MPR1| Mpr300| MPR 300| mpri| N300_10126| N301_02305| N302_02893| N303_01138| N306_14501| N307_03733| N308_04109| N310_05987| N311_12948| N312_05771| N320_03181| N321_14011| N322_01651| N324_09667| N326_03111| N327_01171| N328_02875| N329_11766| N330_12759| N331_10028| N332_05011| N334_13054| N336_02130| N339_08667| N340_12931| N341_10641| PAL_GLEAN10013219| PANDA_014876| TREES_T100014112| UY3_12555| Y1Q_000283| Y956_06350| Z169_15015| igf2r

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