The Function of ID3
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Protein names
Recommended name:
DNA-binding protein inhibitor ID-3Alternative name(s):
Class B basic helix-loop-helix protein 25bHLHb25
Helix-loop-helix protein HEIR-1
ID-like protein inhibitor HLH 1R21
Inhibitor of DNA binding 3
Inhibitor of differentiation 3
- RS11574 (ID3) ??
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Top Gene-Substance Interactions
ID3 Interacts with These Diseases
| Disease | Score |
Substances That Increase ID3
| Substances | Interaction | Organism | Category |
Substances That Decrease ID3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
Gene Pathways:
Induction:
By phorbol 12-myristate 13-acetate (PMA).
Molecular Function:
- Transcription Factor Activity, Sequence-Specific Dna Binding
- Transcription Corepressor Activity
- Leptomycin B Binding
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Metanephros Development
- Regulation Of Dna Replication
- Transcription, Dna-Templated
- Multicellular Organism Development
- Central Nervous System Development
- Heart Development
- Muscle Organ Development
- Circadian Rhythm
- Response To Wounding
- Neuron Differentiation
- Epithelial Cell Differentiation
- Notochord Development
- Odontogenesis
- Positive Regulation Of Apoptotic Process
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Myoblast Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Transcription, Dna-Templated
- Regulation Of Cell Cycle
- Cellular Response To Leptomycin B