The Function of ID3
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.
Protein names
Recommended name:
DNA-binding protein inhibitor ID-3Alternative name(s):
Class B basic helix-loop-helix protein 25bHLHb25
Helix-loop-helix protein HEIR-1
ID-like protein inhibitor HLH 1R21
Inhibitor of DNA binding 3
Inhibitor of differentiation 3
- RS11574 (ID3) ??
To see your genotype, you should be logged in and have a file with your genotype uploaded.
Top Gene-Substance Interactions
ID3 Interacts with These Diseases
| Disease | Score |
Substances That Increase ID3
| Substances | Interaction | Organism | Category |
Substances That Decrease ID3
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.
Gene Pathways:
Induction:
By phorbol 12-myristate 13-acetate (PMA).
Molecular Function:
- Leptomycin B Binding
- Transcription Corepressor Activity
- Transcription Factor Activity, Sequence-Specific Dna Binding
Biological Processes:
- Cellular Response To Leptomycin B
- Central Nervous System Development
- Circadian Rhythm
- Epithelial Cell Differentiation
- Heart Development
- Metanephros Development
- Multicellular Organism Development
- Muscle Organ Development
- Negative Regulation Of Myoblast Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Neuron Differentiation
- Notochord Development
- Odontogenesis
- Positive Regulation Of Apoptotic Process
- Regulation Of Cell Cycle
- Regulation Of Dna Replication
- Response To Wounding
- Transcription, Dna-Templated