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  3. ID3

ID3 (Inhibitor of DNA binding 3, HLH protein)

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The Function of ID3

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer.

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Protein names

Recommended name:

DNA-binding protein inhibitor ID-3

Alternative name(s):

Class B basic helix-loop-helix protein 25
bHLHb25
Helix-loop-helix protein HEIR-1
ID-like protein inhibitor HLH 1R21
Inhibitor of DNA binding 3
Inhibitor of differentiation 3

ID3 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS11574 (ID3) ??

Top Gene-Substance Interactions

ID3 Interacts with These Diseases

Disease Score

Substances That Increase ID3

Substances Interaction Organism Category

Substances That Decrease ID3

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • Egr-1
  • AP-1
  • c-Jun
  • STAT3
  • Nkx2-5
  • AML1a
  • Pax-5

Tissue specificity:

Expressed abundantly in lung, kidney and adrenal gland, but not in adult brain.

Gene Pathways:

  • TGF-beta signaling pathway

Induction:

By phorbol 12-myristate 13-acetate (PMA).

Molecular Function:

  • Leptomycin B Binding
  • Transcription Corepressor Activity
  • Transcription Factor Activity, Sequence-Specific Dna Binding

Biological Processes:

  • Cellular Response To Leptomycin B
  • Central Nervous System Development
  • Circadian Rhythm
  • Epithelial Cell Differentiation
  • Heart Development
  • Metanephros Development
  • Multicellular Organism Development
  • Muscle Organ Development
  • Negative Regulation Of Myoblast Differentiation
  • Negative Regulation Of Osteoblast Differentiation
  • Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
  • Negative Regulation Of Transcription, Dna-Templated
  • Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
  • Neuron Differentiation
  • Notochord Development
  • Odontogenesis
  • Positive Regulation Of Apoptotic Process
  • Regulation Of Cell Cycle
  • Regulation Of Dna Replication
  • Response To Wounding
  • Transcription, Dna-Templated
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| A306_13891| bHLHb25| CB1_000400014| class B basic helix-loop-helix protein 25| DNA-binding protein inhibitor ID-3| DNA-binding protein inhibitor ID-3-A| DNA-binding protein inhibitor ID-3-like protein| EGK_00367| etID138038.17| fa56g03| GW7_07496| H920_06106| heir-1| helix-loop-helix protein| helix-loop-helix protein HEIR-1| Hlh462| Id2d| id3-a| id3-b| Id3 protein| Idb3| ID-like protein inhibitor HLH 1R21| ID-like protein inhibitor HLH 462| ik:tdsubc_2g3| inhibitor of differentiation 3| inhibitor of DNA binding 3| inhibitor of DNA binding 3, dominant negative helix-loop-helix protein| M91_02240| N300_05805| N301_01700| N302_13875| N303_07353| N305_11618| N306_02076| N307_13369| N309_09315| PAL_GLEAN10015163| PANDA_001096| tdsubc_2g3| TREES_T100008805| xid3| xidia| xIdx| xx:tdsubc_2g3| Y1Q_004557| Y956_14861| Z169_08910| id3

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