Summary of ID2
The ID2 gene encodes a protein called inhibitor of DNA binding 2 [R].
ID2 blocks transcriptional regulators from binding to DNA. In this way, it indirectly regulates the expression of other genes. It may also play a role in reducing the rate of cell growth and division [R].
ID2 also helps regulate the circadian rhythms (internal clock). It alters the expression of circadian genes like CLOCK and BMAL1 [R].
Variants in ID2 have been linked to [R, R, R, R]:
- PR interval
- QRS duration
- Circadian rhythms
- Allergies
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Protein names
Recommended name:
DNA-binding protein inhibitor ID-2Alternative name(s):
Class B basic helix-loop-helix protein 26bHLHb26
Inhibitor of DNA binding 2
Inhibitor of differentiation 2
- RS10174949 (ID2) ??
- RS891058 (ID2) ??
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Top Gene-Substance Interactions
ID2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ID2
| Substances | Interaction | Organism | Category |
Substances That Decrease ID2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in early fetal tissues, including those of the central nervous system.
Gene Pathways:
Developmental stage:
Found in most early fetal tissues but not in the corresponding mature tissues.
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Metanephros Development
- Natural Killer Cell Differentiation
- Thigmotaxis
- Membranous Septum Morphogenesis
- Bundle Of His Development
- Transcription, Dna-Templated
- Multicellular Organism Development
- Adult Locomotory Behavior
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Oligodendrocyte Development
- Regulation Of Lipid Metabolic Process
- Olfactory Bulb Development
- Circadian Regulation Of Gene Expression
- Mammary Gland Epithelial Cell Proliferation
- Regulation Of Circadian Rhythm
- Entrainment Of Circadian Clock By Photoperiod
- Enucleate Erythrocyte Differentiation
- Negative Regulation Of Dna Binding
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Locomotor Rhythm
- Negative Regulation Of B Cell Differentiation
- Positive Regulation Of Fat Cell Differentiation
- Positive Regulation Of Erythrocyte Differentiation
- Positive Regulation Of Macrophage Differentiation
- Negative Regulation Of Neuron Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Positive Regulation Of Blood Pressure
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Cell Maturation
- Peyer's Patch Development
- Embryonic Digestive Tract Morphogenesis
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Neuron Fate Commitment
- Cell Morphogenesis Involved In Neuron Differentiation
- Positive Regulation Of Astrocyte Differentiation
- Negative Regulation Of Oligodendrocyte Differentiation
- Adipose Tissue Development
- Mammary Gland Alveolus Development
- Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
- Endodermal Digestive Tract Morphogenesis
- Positive Regulation Of Cell Cycle Arrest
- Cellular Response To Lithium Ion
- Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Cellular Senescence
- Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Neural Precursor Cell Proliferation