The Function of ID2
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Protein names
Recommended name:
DNA-binding protein inhibitor ID-2Alternative name(s):
Class B basic helix-loop-helix protein 26bHLHb26
Inhibitor of DNA binding 2
Inhibitor of differentiation 2
Top Gene-Substance Interactions
ID2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ID2
| Substances | Interaction | Organism | Category |
Substances That Decrease ID2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in early fetal tissues, including those of the central nervous system.
Gene Pathways:
Developmental stage:
Found in most early fetal tissues but not in the corresponding mature tissues.
Molecular Function:
Biological Processes:
- Adipose Tissue Development
- Adult Locomotory Behavior
- Bundle Of His Development
- Cell Maturation
- Cell Morphogenesis Involved In Neuron Differentiation
- Cellular Response To Lithium Ion
- Cellular Senescence
- Circadian Regulation Of Gene Expression
- Embryonic Digestive Tract Morphogenesis
- Endodermal Digestive Tract Morphogenesis
- Entrainment Of Circadian Clock By Photoperiod
- Enucleate Erythrocyte Differentiation
- Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
- Locomotor Rhythm
- Mammary Gland Alveolus Development
- Mammary Gland Epithelial Cell Proliferation
- Membranous Septum Morphogenesis
- Metanephros Development
- Multicellular Organism Development
- Natural Killer Cell Differentiation
- Negative Regulation Of B Cell Differentiation
- Negative Regulation Of Dna Binding
- Negative Regulation Of Gene Expression
- Negative Regulation Of Neural Precursor Cell Proliferation
- Negative Regulation Of Neuron Differentiation
- Negative Regulation Of Oligodendrocyte Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Negative Regulation Of Transcription, Dna-Templated
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Neuron Fate Commitment
- Olfactory Bulb Development
- Oligodendrocyte Development
- Peyer's Patch Development
- Positive Regulation Of Astrocyte Differentiation
- Positive Regulation Of Blood Pressure
- Positive Regulation Of Cell Cycle Arrest
- Positive Regulation Of Erythrocyte Differentiation
- Positive Regulation Of Fat Cell Differentiation
- Positive Regulation Of Gene Expression
- Positive Regulation Of Macrophage Differentiation
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Positive Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Regulation Of Circadian Rhythm
- Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Regulation Of Lipid Metabolic Process
- Thigmotaxis
- Transcription, Dna-Templated