The Function of ID2
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
Protein names
Recommended name:
DNA-binding protein inhibitor ID-2Alternative name(s):
Class B basic helix-loop-helix protein 26bHLHb26
Inhibitor of DNA binding 2
Inhibitor of differentiation 2
Top Gene-Substance Interactions
ID2 Interacts with These Diseases
| Disease | Score |
Substances That Increase ID2
| Substances | Interaction | Organism | Category |
Substances That Decrease ID2
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
|---|
Technical
The following transcription factors affect gene expression:
Tissue specificity:
Highly expressed in early fetal tissues, including those of the central nervous system.
Gene Pathways:
Developmental stage:
Found in most early fetal tissues but not in the corresponding mature tissues.
Molecular Function:
Biological Processes:
- Negative Regulation Of Transcription From Rna Polymerase Ii Promoter
- Metanephros Development
- Natural Killer Cell Differentiation
- Thigmotaxis
- Membranous Septum Morphogenesis
- Bundle Of His Development
- Transcription, Dna-Templated
- Multicellular Organism Development
- Adult Locomotory Behavior
- Positive Regulation Of Gene Expression
- Negative Regulation Of Gene Expression
- Oligodendrocyte Development
- Regulation Of Lipid Metabolic Process
- Olfactory Bulb Development
- Circadian Regulation Of Gene Expression
- Mammary Gland Epithelial Cell Proliferation
- Regulation Of Circadian Rhythm
- Entrainment Of Circadian Clock By Photoperiod
- Enucleate Erythrocyte Differentiation
- Negative Regulation Of Dna Binding
- Negative Regulation Of Sequence-Specific Dna Binding Transcription Factor Activity
- Locomotor Rhythm
- Negative Regulation Of B Cell Differentiation
- Positive Regulation Of Fat Cell Differentiation
- Positive Regulation Of Erythrocyte Differentiation
- Positive Regulation Of Macrophage Differentiation
- Negative Regulation Of Neuron Differentiation
- Negative Regulation Of Osteoblast Differentiation
- Positive Regulation Of Blood Pressure
- Negative Regulation Of Transcription, Dna-Templated
- Positive Regulation Of Transcription, Dna-Templated
- Cell Maturation
- Peyer's Patch Development
- Embryonic Digestive Tract Morphogenesis
- Positive Regulation Of Smooth Muscle Cell Proliferation
- Neuron Fate Commitment
- Cell Morphogenesis Involved In Neuron Differentiation
- Positive Regulation Of Astrocyte Differentiation
- Negative Regulation Of Oligodendrocyte Differentiation
- Adipose Tissue Development
- Mammary Gland Alveolus Development
- Epithelial Cell Differentiation Involved In Mammary Gland Alveolus Development
- Endodermal Digestive Tract Morphogenesis
- Positive Regulation Of Cell Cycle Arrest
- Cellular Response To Lithium Ion
- Positive Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
- Cellular Senescence
- Regulation Of G1/S Transition Of Mitotic Cell Cycle
- Negative Regulation Of Neural Precursor Cell Proliferation