Summary of IBSP
The gene codes for a protein, integrin binding sialoprotein. It is an important structural protein of the bone matrix [R].
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The Function of IBSP
Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.
Protein names
Recommended name:
Bone sialoprotein 2Short name:
BSP IIAlternative name(s):
Bone sialoprotein IICell-binding sialoprotein
Integrin-binding sialoprotein
- RS1054627 (IBSP) ??
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Top Gene-Substance Interactions
IBSP Interacts with These Diseases
| Disease | Score |
Substances That Increase IBSP
| Substances | Interaction | Organism | Category |
Substances That Decrease IBSP
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Technical
The following transcription factors affect gene expression:
Gene Pathways:
Biological Processes:
- Osteoblast Differentiation
- Cell Adhesion
- Extracellular Matrix Organization
- Bone Mineralization
- Cellular Response To Growth Factor Stimulus