Summary of HTR7
The gene codes for a protein, 5-hydroxytryptamine receptor 7. It plays a role in various cognitive and behavioral functions [R].
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The Function of HTR7
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
Protein names
Recommended name:
5-hydroxytryptamine receptor 7Short name:
5-HT7Alternative name(s):
5-HT-75-HT-X
Serotonin receptor 7
- RS12249377 (HTR7) ??
- RS1935349 (HTR7) ??
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Top Gene-Substance Interactions
HTR7 Interacts with These Diseases
| Disease | Score |
Substances That Increase HTR7
| Substances | Interaction | Organism | Category |
Substances That Decrease HTR7
| Substances | Interaction | Organism | Category |
Conditions with Increased Gene Activity
| Condition | Change (log2fold) | Comparison | Species | Experimental variables | Experiment name |
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Conditions with Decreased Gene Activity
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Technical
The following transcription factors affect gene expression:
Tissue specificity:
Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.
Gene Pathways:
Molecular Function:
Biological Processes:
- Smooth Muscle Contraction
- G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
- Adenylate Cyclase-Activating Serotonin Receptor Signaling Pathway
- Chemical Synaptic Transmission
- Circadian Rhythm
- Blood Circulation
- Vasoconstriction
Drug Bank:
- Amisulpride
- Ergoloid Mesylate
- Lurasidone
- Amoxapine
- Asenapine
- Bromocriptine
- Cabergoline
- Chlorpromazine
- Clozapine
- Dopamine
- Epinastine
- Iloperidone
- Imipramine
- Loxapine
- Methysergide
- Mianserin
- Mirtazapine
- Olanzapine
- Quetiapine
- Ziprasidone
- Amitriptyline
- Aripiprazole
- Eletriptan
- Maprotiline
- Vortioxetine