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  3. HTR7

HTR7 (5-hydroxytryptamine receptor 7)

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Summary of HTR7

The gene codes for a protein, 5-hydroxytryptamine receptor 7. It plays a role in various cognitive and behavioral functions [R].

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The Function of HTR7

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.

Protein names

Recommended name:

5-hydroxytryptamine receptor 7

Short name:

5-HT7

Alternative name(s):

5-HT-7
5-HT-X
Serotonin receptor 7

HTR7 SNPs

    To see your genotype, you should be logged in and have a file with your genotype uploaded.

  1. RS12249377 (HTR7) ??
  2. RS1935349 (HTR7) ??

Top Gene-Substance Interactions

HTR7 Interacts with These Diseases

Disease Score

Substances That Increase HTR7

Substances Interaction Organism Category

Substances That Decrease HTR7

Substances Interaction Organism Category

Conditions with Increased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Conditions with Decreased Gene Activity

Condition Change (log2fold) Comparison Species Experimental variables Experiment name

Technical

The following transcription factors affect gene expression:

  • CREB
  • deltaCREB
  • Sp1

Tissue specificity:

Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in term of expression.

Gene Pathways:

  • Signal Transduction
  • Neuroactive ligand-receptor interaction
  • Calcium signaling pathway

Molecular Function:

  • G-Protein Coupled Serotonin Receptor Activity
  • Neurotransmitter Receptor Activity

Biological Processes:

  • Adenylate Cyclase-Activating Serotonin Receptor Signaling Pathway
  • Blood Circulation
  • Chemical Synaptic Transmission
  • Circadian Rhythm
  • G-Protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
  • Smooth Muscle Contraction
  • Vasoconstriction

Drug Bank:

  • Amisulpride
  • Ergoloid Mesylate
  • Lurasidone
  • Amoxapine
  • Asenapine
  • Bromocriptine
  • Cabergoline
  • Chlorpromazine
  • Clozapine
  • Dopamine
  • Epinastine
  • Iloperidone
  • Imipramine
  • Loxapine
  • Methysergide
  • Mianserin
  • Mirtazapine
  • Olanzapine
  • Quetiapine
  • Ziprasidone
  • Amitriptyline
  • Aripiprazole
  • Eletriptan
  • Maprotiline
  • Vortioxetine
*synonyms

Synonyms/Aliases/Alternative Names of the Gene:

hypothetical protein| 5-ht7| 5Ht7| 5-HT-7| 5-HT7 receptor| 5-HT receptor 7a| 5-HT-X| 5-hydroxytryptamine 7 receptor| 5-hydroxytryptamine7 receptor| 5-hydroxytryptamine (serotonin) receptor 7| 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)| 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled| Anapl_03536| AS27_02610| AS28_04456| CB1_000689030| D623_10028851| GPRFO| H920_08680| high affinity serotonin receptor (5HT7)| I79_004939| M91_18026| M959_09888| MDA_GLEAN10014860| N300_07498| N301_10640| N302_13493| N305_11464| N306_13870| N307_06146| N308_09036| N330_05281| N331_09625| N334_00682| PAL_GLEAN10018375| serotonin 5-hydroxytryptamine 7-a receptor| serotonin receptor 7| Y1Q_023580| Y956_01514| htr7

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